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Author: Masoud Mozafari
Publisher: Woodhead Publishing
ISBN: 0128236108
Category : Medical
Languages : en
Pages : 492
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Book Description
Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips
Author: Masoud Mozafari
Publisher: Woodhead Publishing
ISBN: 0128236108
Category : Medical
Languages : en
Pages : 492
Get Book
Book Description
Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips
Author: Margarita Stoytcheva
Publisher: BoD – Books on Demand
ISBN: 9535124579
Category : Science
Languages : en
Pages : 210
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Book Description
The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.
Author: Jing Cheng
Publisher: CRC Press
ISBN: 0203305043
Category : Science
Languages : en
Pages : 453
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Book Description
Biochip technology has experienced explosive growth in recent years and Biochip technology describes the basic manufacturing and fabrication processes and the current range of applications of these chips. Top scientists from the biochip industry and related areas explain the diverse applications of biochips in gene sequencing, expression monitoring, disease diagnosis, tumor examination, ligand assay and drug discovery.
Author: Christopher Bettinger
Publisher: William Andrew
ISBN: 143773460X
Category : Science
Languages : en
Pages : 452
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Book Description
The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering
Author: Cornelia Kasper
Publisher: Springer Nature
ISBN: 3030667499
Category : Medical
Languages : en
Pages : 252
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Book Description
This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.
Author: Albert Folch
Publisher: MIT Press
ISBN: 026204689X
Category : Technology & Engineering
Languages : en
Pages : 353
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Book Description
Stories behind essential microfluidic devices, from the inkjet printer to DNA sequencing chip. Hidden from view, microfluidics underlies a variety of devices that are essential to our lives, from inkjet printers to glucometers for the monitoring of diabetes. Microfluidics—which refers to the technology of miniature fluidic devices and the study of fluids at submillimeter levels—is invisible to most of us because it is hidden beneath ingenious user interfaces. In this book, Albert Folch, a leading researcher in microfluidics, describes the development and use of key microfluidic devices. He explains not only the technology but also the efforts, teams, places, and circumstances that enabled these inventions. Folch reports, for example, that the inkjet printer was one of the first microfluidic devices invented, and traces its roots back to nineteenth-century discoveries in the behavior of fluid jets. He also describes how rapid speed microfluidic DNA sequencers have enabled the sequencing of animal, plant, and microbial species genomes; organs on chips facilitate direct tests of drugs on human tissue, leapfrogging over the usual stage of animal testing; at-home pregnancy tests are based on clever microfluidic principles; microfluidics can be used to detect cancer cells in the early stages of metastasis; and the same technology that shoots droplets of ink on paper in inkjet printers enables 3D printers to dispense layers of polymers. Folch tells the stories behind these devices in an engaging style, accessible to nonspecialists. More than 100 color illustrations show readers amazing images of microfluids under the microscope.
Author: Michael R. Hamblin
Publisher: Academic Press
ISBN: 0128187921
Category : Technology & Engineering
Languages : en
Pages : 352
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Book Description
Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students
Author: Wole Soboyejo
Publisher: Cambridge University Press
ISBN: 1108963447
Category : Technology & Engineering
Languages : en
Pages : 374
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Book Description
Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.
Author: Anthony Atala
Publisher: Academic Press
ISBN: 9780123814234
Category : Science
Languages : en
Pages : 1202
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Book Description
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
Author: J. Miguel Oliveira
Publisher: Springer Nature
ISBN: 3030365883
Category : Medical
Languages : en
Pages : 176
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Book Description
This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.
