The Effects of 1,25-Dihydroxyvitamin D3 and Analogues on UVB-irradiated Human Keratinocytes PDF Download
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Author: Petra De Haes
Publisher: Leuven University Press
ISBN: 9789058674289
Category : Keratinocytes
Languages : en
Pages : 178
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Book Description
This is a Ph.D. dissertation. The skin serves as a protective interface between the body and the noxious environment. Ultraviolet (UV) radiation is one of the most important sources of environmental stress, inducing photochemical changes in the skin that may lead to sunburn, premature skin aging and skin cancer. The skin and UV also play a leading part in the vitamin D endocrine system. When UVB photons strike the epidermis, their energy can be used for the synthesis of vitamin D3. Furthermore, the skin is one of the direct target issues for vitamin D3 action. The close interplay between UV and vitamin D3 production in the skin evokes the possibility of mutual interactions. Contents: Introduction, Aims and Scopes of the Study, Materials and Methods, 1,25D3 Inhibits UVB-Induced Apoptosis and IL-6 Production in Human Keratinocytes, 1,25D3 Protects Human Keratinocytes Against UVB-Induced Damage, Two 14-EPI Analogues of 1,25D3 Protect Human Keratinocytes Against Different UVB Effects, Molecular Pathways Involved in the Anti-Apoptotic Effect of 1,25D3 in Human Keratinocytes, General Discussion and Perspectives.
Author: Petra De Haes
Publisher: Leuven University Press
ISBN: 9789058674289
Category : Keratinocytes
Languages : en
Pages : 178
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Book Description
This is a Ph.D. dissertation. The skin serves as a protective interface between the body and the noxious environment. Ultraviolet (UV) radiation is one of the most important sources of environmental stress, inducing photochemical changes in the skin that may lead to sunburn, premature skin aging and skin cancer. The skin and UV also play a leading part in the vitamin D endocrine system. When UVB photons strike the epidermis, their energy can be used for the synthesis of vitamin D3. Furthermore, the skin is one of the direct target issues for vitamin D3 action. The close interplay between UV and vitamin D3 production in the skin evokes the possibility of mutual interactions. Contents: Introduction, Aims and Scopes of the Study, Materials and Methods, 1,25D3 Inhibits UVB-Induced Apoptosis and IL-6 Production in Human Keratinocytes, 1,25D3 Protects Human Keratinocytes Against UVB-Induced Damage, Two 14-EPI Analogues of 1,25D3 Protect Human Keratinocytes Against Different UVB Effects, Molecular Pathways Involved in the Anti-Apoptotic Effect of 1,25D3 in Human Keratinocytes, General Discussion and Perspectives.
Author: Henry W. Lim
Publisher: CRC Press
ISBN: 1420019961
Category : Medical
Languages : en
Pages : 495
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Book Description
Covering the entire array of photodermatological topics necessary to stand at the head of this burgeoning discipline, this source contains expertly written chapters that offer recommendations and guidelines from opinion-forming international authorities. Reviewing the entire range of photodermatoses, as well as the management, treatment, i
Author: Jörg Reichrath
Publisher: Springer Nature
ISBN: 3030462277
Category : Medical
Languages : en
Pages : 428
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Book Description
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Author: A. Giustina
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318063398
Category : Medical
Languages : en
Pages : 206
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Book Description
Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.
Author: Adrian F. Gombart
Publisher: CRC Press
ISBN: 1439850208
Category : Medical
Languages : en
Pages : 465
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Book Description
Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body The role vitamin D plays in modulating oxidative stress—with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases The role vitamin D plays in the regulation of the aging process—including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.
Author: Pierre Andre
Publisher: CRC Press
ISBN: 1315363267
Category : Medical
Languages : en
Pages : 823
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Book Description
Aesthetic rejuvenation now encompasses so many topics that practitioners in one area may feel out of touch with developments in other areas in the same field. With over 70 chapters, over 1200 figures (many in full color), over 80 tables, and over 20 videos, from an international list of contributors, under an eminent team of editors, Cosmetic Medicine & Surgery is a comprehensive and authoritative resource. It covers a wide spectrum of topics including the fundamental aspects, cosmetic aspects, minimally invasive surgery, the aesthetic facelift, and many others in this most high-profile of medical and surgical specialties. Print Versions of this book also include access to the ebook version.
Author: Victor R. Preedy
Publisher: Springer
ISBN: 9086867294
Category : Science
Languages : en
Pages : 487
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Book Description
Studies have clearly shown that optimal diet and nutrition can prevent skin disease. Moreover, novel nutritional components have been used experimentally to treat skin conditions. However, the clinical application of these nutrients awaits confirmation. It is thus up to health care professionals to present new knowledge in order to provide advice or treatments for skin problems. This handbook provides, in a single volume, comprehensive coverage of the relation between skin and diet and nutrition in its broadest sense. The Handbook of diet, nutrition and the skin consists of sections on general aspects of skin, nutrition and diet, micronutrients, nutraceuticals, cancer and specific skin conditions. Unique features of each chapter in this volume include relevant and useful 'key facts' which highlight interesting or important findings of the specific subjects and 'summary points' that are designed to abstract each chapter in take home messages. This handbook will be of interest to a wide range of readers, such as dermatologists, doctors, nurses and those interested in, or working within the area of skin health. This will of course also include nutritionists and dieticians, dermatologists, cosmetic scientists, health workers and practitioners, college and university lecturers and undergraduate and graduate students.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1422
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Book Description
Author: Swati Palit Deb
Publisher: Springer
ISBN: 9789402403572
Category : Medical
Languages : en
Pages : 0
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Book Description
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
Author: Jörg Reichrath
Publisher: Springer
ISBN: 149390437X
Category : Medical
Languages : en
Pages : 539
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Book Description
The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV‐exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in‐depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up‐to‐date information for every clinician or scientist interested in how to balance between positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
