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Author: Stuart G. Siddell
Publisher: Springer Science & Business Media
ISBN: 1489915311
Category : Medical
Languages : en
Pages : 424
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Book Description
Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.
Author: Stuart G. Siddell
Publisher: Springer Science & Business Media
ISBN: 1489915311
Category : Medical
Languages : en
Pages : 424
Get Book
Book Description
Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309182158
Category : Medical
Languages : en
Pages : 376
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Book Description
The emergence of severe acute respiratory syndrome (SARS) in late 2002 and 2003 challenged the global public health community to confront a novel epidemic that spread rapidly from its origins in southern China until it had reached more than 25 other countries within a matter of months. In addition to the number of patients infected with the SARS virus, the disease had profound economic and political repercussions in many of the affected regions. Recent reports of isolated new SARS cases and a fear that the disease could reemerge and spread have put public health officials on high alert for any indications of possible new outbreaks. This report examines the response to SARS by public health systems in individual countries, the biology of the SARS coronavirus and related coronaviruses in animals, the economic and political fallout of the SARS epidemic, quarantine law and other public health measures that apply to combating infectious diseases, and the role of international organizations and scientific cooperation in halting the spread of SARS. The report provides an illuminating survey of findings from the epidemic, along with an assessment of what might be needed in order to contain any future outbreaks of SARS or other emerging infections.
Author: Raul Rabadan
Publisher: Cambridge University Press
ISBN: 1009086650
Category : Science
Languages : en
Pages : 167
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Book Description
Since the identification of the first cases of the coronavirus in December 2019, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the virus, unproven therapies, and inconsistent public health measures, have all served to increase anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? In this concise and accessible introduction, a leading expert provides answers to these commonly asked questions. This revised and updated edition now also covers how the virus mutates, how important these mutations are, how vaccines work, and what we can expect in the near and long-term future.
Author: Raul Rabadan
Publisher: Cambridge University Press
ISBN: 1108922139
Category : Science
Languages : en
Pages : 137
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Book Description
Since the identification of the first cases of the coronavirus in December 2019 in Wuhan, China, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', officially named SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the newly emerging virus and the inconsistent public health measures across different countries, have all served to increase the level of anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? What can we do to stop its spread? Written by a leading expert, this concise and accessible introduction provides answers to the most common questions surrounding coronavirus for a general audience.
Author: Mohamad Hesam Shahrajabian
Publisher:
ISBN: 9781536182590
Category : Coronaviruses
Languages : en
Pages : 161
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Book Description
The coronaviruses are ssRNA viruses that infect a wide range of mammalian and avian species; they are important causes of respiratory and enteric disease, encephalomyelitis, hepatitis, serositis and vasculitis domestic animals. In humans coronaviruses are one of several groups of viruses that cause the common cold. The genus Coronavirus together with the genus Torovirus from the family Coronaviridae; members of these two genera are similar morphologically. The Coronaviridae, Arteriviridae, and Roniviridae are within the order Nidovirales. Seven coronaviruses are known to infect humans, three of them are serious, namely, SARS (severe acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (2019-2020). SARS is caused by a coronavirus (SARS-CoV) which exists in bats and palm civets in Southern China. Its family is Coronaviridae, and its genus is Coronavirus. The most important groups who are at risk are family members in close contact with cases, health-care workers in close contact with cases, elderly and immune compromised individuals appear at increased risk. MERS-CoV is a zoonotic virus which can lead to secondary human infections. It is the sixth coronavirus that influences human. MERS-CoV is most likely derived from an ancestral reservoir bats. MERS outbreak was found in the Republic of Korea since 2015. Coronavirus entry is initiated by the binding of the spike protein (S) to cell receptors, specifically, dipeptidyl peptidase 4 (DDP4) and angiotensin converting enzyme 2 (ACE2) for MERS-CoV and SARS-CoV, respectively. The genome sequence analysis has shown that SARS-CoV-2 belongs to betacoronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. On the basis of nucleic acid sequence similarity, the newly identified 2019-nCoV is a betacoronavirus. The RBD portion of the SARS-CoV-2 pike proteins has evolved to effectively target a molecular feature on the outside of human cells called ACE2, a receptor involved in regulating blood pressure. The SARS-CoV-2 spike protein was found so effective at binding the human cells. In SARS-CoV-2, M protein is responsible for the transmembrane transport of nutrient, the bud release and the formation of envelope, S protein, attaching to hose receptor ACE2, including two subunits S1 and S2. These diseases can be considered important models for emerging infectious diseases as it emerged from natural animal reservoirs. Early recognition, prompt isolation and appropriate supportive therapy are the main parameters in combating with these deadly infections.
Author: Delthia Ricks
Publisher: Jones & Bartlett Learning
ISBN: 128423049X
Category : Medical
Languages : en
Pages : 213
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Book Description
100 Questions & Answers About Coronaviruses is a timely resource that organizes and distills cutting-edge information and data on COVID-19 in a single, convenient, easy-to-read resource. Featuring a foreword by Dr. Aaron Glatt, Chairman and Chief of Infectious Diseases and Hospital Epidemiologist at Mount Sinai South Nassau, 100 Questions and Answers About Coronaviruses begins with a history and myths about coronaviruses and progresses to answer questions about how COVID-19 affects children and adults, current vaccine research, quarantine, social distancing, preventing future pandemics, and more often asked questions. 100 Questions & Answers About Coronaviruses is a must-read for anyone interested in learning about the coronavirus that has reshaped our daily lives.
Author: Renae Gilles
Publisher: Lerner Publications ™
ISBN: 1728428750
Category : Juvenile Nonfiction
Languages : en
Pages : 32
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Book Description
COVID-19 has taken the entire world by storm. Many of the smartest people on Earth have been working to find treatments, a vaccine, and ultimately, a cure. So what exactly is COVID-19? What is a "coronavirus"? Where did the disease come from? How do you know if you have it? How is it treated? How do you stop yourself from getting it or passing it on to others? Learn all about the answers to these questions, and one more question on everyone's mind: When and how will the world go back to normal?
Author: Clyde Dapat
Publisher: Frontiers Media SA
ISBN: 2889765296
Category : Science
Languages : en
Pages : 128
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Book Description
Author: Dave Cavanagh
Publisher: Springer Science & Business Media
ISBN: 9781588298676
Category : Medical
Languages : en
Pages : 368
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Book Description
In 2003, the word "coronavirus" spread across the globe, somewhat further than the virus that sparked the panic. In this book, expert researchers examine these devastating viruses through 23 state-of-the-art, widely applicable protocols with minute detail. Comprehensive and cutting-edge, the book serves as an ideal guide for all virologists and especially for those working with coronaviruses. Written by international experts, this book is relevant to a wide array of professions.
Author: Leyi Wang
Publisher: Springer Protocols Handbooks
ISBN: 9781493980444
Category : Medical
Languages : en
Pages : 230
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Book Description
This detailed volume provides diagnosticians and researchers with practical methodologies and approaches to tackle animal coronaviruses. It explores conventional immunohistochemistry, virus neutralization, enzyme-linked immunosorbent assays, expression and purification of recombinant viral proteins, and various molecular assays, including conventional and real-time reverse transcription-PCR, reverse genetics methodology, and next generation sequencing and sequence analyses. As part of the Springer Protocols Handbooks series, chapters contain readily reproducible laboratory protocols as well as expert tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Animal Coronaviruses serves as an ideal reference for researchers examining a wide variety of coronavirus species in the Coronaviridae.
