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Author: Ramsey Campbell
Publisher: Simon and Schuster
ISBN: 178758559X
Category : Fiction
Languages : en
Pages : 256
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Book Description
Featured in Library Journal's Top 20 Horror Bestseller List “An absolute master of modern horror. And a damn fine writer at that” - Guillermo del Toro Book 1 in the Three Births of Daoloth trilogy. 1952. On a school trip to France teenager Dominic Sheldrake begins to suspect his teacher Christian Noble has reasons to be there as secret as they're strange. Meanwhile a widowed neighbour joins a church that puts you in touch with your dead relatives, who prove much harder to get rid of. As Dominic and his friends Roberta and Jim investigate, they can’t suspect how much larger and more terrible the link between these mysteries will become. A monstrous discovery beneath a church only hints at terrors that are poised to engulf the world as the trilogy brings us to the present day… FLAME TREE PRESS is the new fiction imprint of Flame Tree Publishing. Launched in 2018 the list brings together brilliant new authors and the more established; the award winners, and exciting, original voices.
Author: Ramsey Campbell
Publisher: Simon and Schuster
ISBN: 178758559X
Category : Fiction
Languages : en
Pages : 256
Get Book
Book Description
Featured in Library Journal's Top 20 Horror Bestseller List “An absolute master of modern horror. And a damn fine writer at that” - Guillermo del Toro Book 1 in the Three Births of Daoloth trilogy. 1952. On a school trip to France teenager Dominic Sheldrake begins to suspect his teacher Christian Noble has reasons to be there as secret as they're strange. Meanwhile a widowed neighbour joins a church that puts you in touch with your dead relatives, who prove much harder to get rid of. As Dominic and his friends Roberta and Jim investigate, they can’t suspect how much larger and more terrible the link between these mysteries will become. A monstrous discovery beneath a church only hints at terrors that are poised to engulf the world as the trilogy brings us to the present day… FLAME TREE PRESS is the new fiction imprint of Flame Tree Publishing. Launched in 2018 the list brings together brilliant new authors and the more established; the award winners, and exciting, original voices.
Author: Robert A. Neimeyer
Publisher: Taylor & Francis
ISBN: 131776367X
Category : Self-Help
Languages : en
Pages : 312
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Book Description
First published in 1994. Routledge is an imprint of Taylor & Francis, an informa company.
Author: William G Warren
Publisher: Routledge
ISBN: 131777356X
Category : Education
Languages : en
Pages : 232
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Book Description
A critical review of research and reflection in the area of death, with special emphasis on death education. Thought-provoking, often controversial reviews of and reactions to the current general domain of death phenomena--specifically death education--are addressed in this book. The author, skeptical that we can do very much with the phenomenon of death and dying, especially in relation to our efforts at addressing it educationally, explores the philosophical, psychological, socio-cultural, and theoretical aspects and raises critical questions that will challenge proponents of death education. Both advocates and critics of death education in particular, and death research in general, will benefit from this intellectually stimulating volume that sounds a cautionary note, yet offers some positive suggestions for the future of death education. Professionals interested in any aspect of death education will be intrigued by this thorough examination of death education from several perspectives.
Author: Christopher M. DeGiorgio
Publisher: Frontiers Media SA
ISBN: 2889455947
Category :
Languages : en
Pages : 71
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Book Description
Sudden Death in Epilepsy (SUDEP) is a major cause of death in people with epilepsy, accounting for up to 17% of all deaths. Research interest is exploding, focusing on epidemiology, basic mechanisms, identification of risk factors, and biomarkers. New wearable technologies are approved or in development. These incorporate accelerometers and advanced heart rate detection, which are linked to smart phones. The advent of FDA approved detection devices now allows immediate intervention by family and loved ones. The next frontier for SUDEP remains effective prevention strategies, which will likely include new devices and pharmacologic interventions. This volume is organized into three sections: Basic and Physiologic Mechanisms; Clinical Risk Factors and Inventories; and Very Early Research into Pharmacologic Interventions. It is our hope that this eBook will inform clinicians of key advances in the field, and to foster and stimulate basic and translational research with one purpose: To prevent SUDEP in those at risk.
Author: National Institute of Child Health and Human Development (U.S.). Perinatal Biology and Infant Mortality Branch
Publisher:
ISBN:
Category : Sudden infant death syndrome
Languages : en
Pages : 128
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Book Description
Author:
Publisher:
ISBN:
Category : Sudden infant death syndrome
Languages : en
Pages : 170
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Book Description
Author:
Publisher:
ISBN:
Category : Geological mapping
Languages : en
Pages : 194
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Book Description
Author:
Publisher:
ISBN:
Category : Grief
Languages : en
Pages : 112
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Book Description
Author: National Institute of Child Health and Human Development (U.S.). Pregnancy and Infancy Branch
Publisher:
ISBN:
Category : Sudden death in infants
Languages : en
Pages : 100
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Book Description
Author: Abhishek D Garg
Publisher: Frontiers Media SA
ISBN: 2889198383
Category : Electronic book
Languages : en
Pages : 147
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Book Description
Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.
