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Author: Philip R. Dormitzer
Publisher: Springer Science & Business Media
ISBN: 3034602774
Category : Medical
Languages : en
Pages : 447
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Book Description
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
Author: Philip R. Dormitzer
Publisher: Springer Science & Business Media
ISBN: 3034602774
Category : Medical
Languages : en
Pages : 447
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Book Description
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
Author: Marc Willems
Publisher:
ISBN: 3750419132
Category :
Languages : en
Pages : 250
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Book Description
Author: Fouad Sabry
Publisher: One Billion Knowledgeable
ISBN:
Category : Computers
Languages : en
Pages : 147
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Book Description
What Is Self Replicating Machine A self-replicating machine is a sort of autonomous robot that is capable of reproducing itself autonomously utilizing raw materials available in the environment. As a result, a self-replicating machine demonstrates self-replication in a manner that is akin to that which may be found in nature. The idea of self-replicating machines has been developed and investigated by Homer Jacobson, Edward F. Moore, Freeman Dyson, John von Neumann, and Konrad Zuse, as well as more recently by K. Eric Drexler in his book on nanotechnology titled Engines of Creation, as well as by Robert Freitas and Ralph Merkle in their review Kinematic Self-Replicating Machines, which provided the first comprehensive analysis of the entire replicator design space. The future development of such technology is an essential component of a number of schemes involving the extraction of ore and other resources from moons and asteroid belts, the establishment of manufacturing facilities on the moon, and even the building of solar power satellites in space. These plans are all reliant on the future progress of this technology. The von Neumann probe is a conceptual illustration of one hypothetical example of such a machine. In addition to this, Von Neumann worked on a project that he referred to as the universal constructor. This was a self-replicating machine that would be capable of evolving, and it was an environment that was codified using cellular automata. Notably, Von Neumann's Self-Reproducing Automata scheme proposed that in order for open-ended evolution to occur, inherited information must be copied and passed on to offspring in a manner that is distinct from the self-replicating machine. This realization came before Watson and Crick's discovery of the structure of the DNA molecule and how it is independently translated and replicated in the cell. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Self-replicating machine Chapter 2: Molecular nanotechnology Chapter 3: Robert Freitas Chapter 4: Ralph Merkle Chapter 5: Self-replication Chapter 6: Von Neumann universal constructor Chapter 7: Self-replicating spacecraft Chapter 8: Molecular assembler Chapter 9: Mechanosynthesis Chapter 10: Nanorobotics (II) Answering the public top questions about self replicating machine. (III) Real world examples for the usage of self replicating machine in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of self replicating machine' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of self replicating machine.
Author: Khadija Monk
Publisher: Taylor & Francis
ISBN: 104002002X
Category : Social Science
Languages : en
Pages : 107
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Book Description
This book addresses the need for policing scholarship to strengthen its empirical cumulative knowledge base by replicating and reproducing earlier studies. The chapters in this volume advance policing research by replicating and reproducing earlier studies, investigating the generalizability of research findings, and making data and research methods available to other researchers to encourage scientific exploration of previous research findings. Each chapter addresses important scientific goals of validity, reliability, and generalizability, which build our cumulative knowledge of what is known in policing research, ultimately informing policymaking. The book offers insights into why replicating and reproducing policing scholarship is critical; from emphasizing the importance of making data and study material publicly available to facilitate replications and reproductions, to reproducing studies in new contexts and cautioning against making policy-making decisions based on studies that have not been replicated. This volume highlights the immense value in shifting researchers’ priorities – even slightly – to focus less so on originality and innovation to make room for replications and reproductions, thereby shedding light on how true, empirical knowledge on policing and police practice is dependent on it. This book was originally published as a special issue of Police Practice and Research.
Author: Kenneth N Kreuzer
Publisher: World Scientific
ISBN: 9811215715
Category : Science
Languages : en
Pages : 438
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Book Description
Replicating and Repairing the Genome provides a concise overview of the fields of DNA replication and repair. The book is particularly appropriate for graduate students and advanced undergraduates, and scientists entering the field or working in related fields. The breadth of information regarding DNA replication and repair is vast and often difficult to absorb, with terminology that differs between experimental systems and with complex interconnections of these processes with other cellular pathways. This book provides simple conceptual descriptions of replication and repair pathways using mostly generic protein names, laying out the logic for how the pathways function and highlighting fascinating aspects of the underlying biochemical mechanisms and biology. The book incorporates extensive and informative diagrams and figures, as well as descriptions of a number of carefully chosen experiments that had major influences in the field.The process of DNA replication is explained progressively by starting with the system of a simple bacterial virus that uses only a few proteins, followed by the well-understood bacterial (E coli) system, and then culminating with the more complex eukaryotic systems. In the second half of the book, individual chapters cover key areas of DNA repair — postreplication repair of mismatches and incorporated ribonucleotides, direct damage reversal, excision repair, and DNA break repair, as well as the related areas of DNA damage tolerance (including translesion DNA polymerases) and DNA damage responses. The book closes with chapters that describe the huge impact of DNA replication and repair on aspects of human health and on modern biotechnology.
Author:
Publisher:
ISBN:
Category : Handicapped
Languages : en
Pages : 250
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Book Description
Author: Robby Gallaty
Publisher: Moody Publishers
ISBN: 0802498906
Category : Religion
Languages : en
Pages : 336
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Book Description
A Practical Guide to Creating and Sustaining a Culture of Disciple-Making in Any Church Over the last few decades American churches have produced plenty of converts but not as many mature believers. Studies show the majority of Christians don’t even understand the basics of faith. But how do you tackle such a big problem? Replicate shows church leaders how to make disciples who make disciples and get the rest of your church on board as well. This one-on-one relational ministry is how Jesus laid the foundation for His church that is still growing today, and it’s how we continue the work in our own local congregations. Learn the five marks of a healthy disciple-making church, how to influence culture, uproot misconceptions of the church and the gospel, and change your church and community. No more focusing on mere numbers, it’s time to grow in maturity and through multiplication.
Author: Daniel L. Kaplan
Publisher: Springer
ISBN: 3319246968
Category : Medical
Languages : en
Pages : 563
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Book Description
Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309486165
Category : Science
Languages : en
Pages : 257
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Book Description
One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.
