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Author: Michael K. Pugsley
Publisher: Springer
ISBN: 366246943X
Category : Medical
Languages : en
Pages : 481
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Book Description
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author: Michael K. Pugsley
Publisher: Springer
ISBN: 366246943X
Category : Medical
Languages : en
Pages : 481
Get Book
Book Description
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author: Mary Jeanne Kallman
Publisher: Academic Press
ISBN: 0128123346
Category : Medical
Languages : en
Pages : 360
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Book Description
Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues. Focuses on pharmacology issues that result during drug development and provides de-risking techniques and practical advice Covers a broad selection of topics, including specialized animal models, PBPK modeling, the use of high frequency EEG in problem-solving, drug-induced self-injury, abuse potential liability, biomarkers, imaging, and much more Focuses on the resolution of these issues in order to better address regulatory expectancies and develop safer, more effective drugs
Author: Y. James Kang
Publisher:
ISBN: 9781597453080
Category :
Languages : en
Pages : 400
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Book Description
Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 1439845689
Category : Medical
Languages : en
Pages : 213
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Book Description
Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard-particularly in individuals with compromised or limited organ system functions.Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Su
Author: Benjamin E. Blass
Publisher: Academic Press
ISBN: 0128172150
Category : Medical
Languages : en
Pages : 712
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Book Description
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Author: M. Linda Workman
Publisher: Elsevier Health Sciences
ISBN: 0323339212
Category : Medical
Languages : en
Pages : 560
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Book Description
Pharmacology can be difficult. But with the right text, understanding drugs and how they work doesn’t have to be! Using easy-to-follow language and engaging learning tools — like Memory Joggers, Clinical Pitfalls, Do Not Confuse, and Drug Alerts — the second edition of Understanding Pharmacology: Essentials for Medication Safety helps readers really understand how drugs work. In addition to the popular critical thinking activities from the first edition, the second edition also includes more chapter review questions, updated content, and a new organization that centers on the different body systems. For students who have a limited background in the sciences and want complete preparation for licensure exams and clinical practice, there is no better choice than Understanding Pharmacology, 2nd Edition! Entire unit reviewing math, weights and measures, and dosage calculation minimizes readers’ anxiety and promotes medication safety. Clever, easy-to-recognize margin icons help visual learners remember essential side effects of drugs. Simplified heading structure replaces intimidating terminology (i.e. pharmacokinetics) with simplified language (How These Drugs Work) to increase understanding of concepts. Drug Alert!, Do-Not-Confuse, and Clinical Pitfall boxes highlight important tips for safe medication administration. Memory Jogger boxes help readers remember important drug information. Get Ready for Practice sections at the end of each chapter include key points, chapter review questions, and critical thinking activities to reinforce learning. 10th grade reading level uses straightforward, everyday language to really enhance readers’ understanding of pharmacology concepts. Incorporation of adult learning theory features both a simple to complex organization of material along with answers to why readers need to learn something. NEW! Body system organization helps readers better understand drugs that are specific to particular body systems. NEW! More chapter review questions have been added to the text. All review questions are now organized into one of two categories: Test Yourself on the Basics and Test Yourself on Advanced Concepts.
Author: James E. Barrett
Publisher: Springer Nature
ISBN: 3030353621
Category : Medical
Languages : en
Pages : 466
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Book Description
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Author: Arthur J. Atkinson, Jr.
Publisher: Elsevier
ISBN: 9780080466422
Category : Medical
Languages : en
Pages : 568
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Book Description
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry Expanded coverage of pharmacogenetics Expanded coverage of drug transporters and their role in interactions Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions A new chapter on drug discovery that focuses on oncologic agents Inclusion of therapeutic antibodies in chapter on biotechnology products
Author: Shiew-Mei Huang
Publisher: Academic Press
ISBN: 0128198842
Category : Medical
Languages : en
Pages : 764
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Book Description
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Author: Joel E. Houglum
Publisher: SLACK Incorporated
ISBN: 1556429010
Category : Medical
Languages : en
Pages : 482
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Book Description
Principles of Pharmacology for Athletic Trainers, Second Edition has expanded the comprehensive and unique aspect of pharmacology presented in the best-selling first edition by introducing new information on: * Drug and treatment strategies. * Aspects of Type 1 and Type 2 diabetes, including treatment strategies, the disease process, diagnosis & monitoring of diabetes, and issues that are important for the athletic trainer. * The foundational concepts and pharmacological treatment of schizophrenia, depression, bipolar disorder, various anxiety disorders, and attention deficit-hyperactivity disorder. * Discussion of herbal supplements, federal regulations, and safety & quality issues related to herbal supplements. Dr. Joel Houglum and Dr. Gary Harrelson have updated Principles of Pharmacology for Athletic Trainers, Second Edition to be more user-friendly by incorporating revised information on pharmacokinetic and pharmacodynamic principles, making it even easier for students to understand, while still providing the depth of information desired by faculty. Features of the Second Edition: * Educational prompts are provided in each chapter in the form of an advanced chapter organizer. * Shadow boxes throughout to remind students of previously discussed topics. * Summaries at the end of each section to reinforce learning. * A section in each chapter on the role of the athletic trainer regarding the disease process and drug therapy. * New ancillary materials specifically for faculty that include PowerPoint slides and test bank questions. Principles of Pharmacology for Athletic Trainers, Second Edition will be the go-to resource to determine the best pharmacological treatment strategy and management by athletic trainers.
