Primary Progressive Multiple Sclerosis PDF Download
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Author: Nancy J. Holland
Publisher: Diamedica
ISBN: 9780982321904
Category : Multiple sclerosis
Languages : en
Pages : 0
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Book Description
Primary progressive multiple sclerosis (PPMS) affects approximately 10% of the MS population, and is characterized by a steady decline in function, without relapses. This book is geared to the wide variety of physical and emotional issues of people with PPMS and their families. It explains the nature and characteristics of the disease, as well as comprehensive multidisciplinary management.
Author: Nancy J. Holland
Publisher: Diamedica
ISBN: 9780982321904
Category : Multiple sclerosis
Languages : en
Pages : 0
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Book Description
Primary progressive multiple sclerosis (PPMS) affects approximately 10% of the MS population, and is characterized by a steady decline in function, without relapses. This book is geared to the wide variety of physical and emotional issues of people with PPMS and their families. It explains the nature and characteristics of the disease, as well as comprehensive multidisciplinary management.
Author: M. Filippi
Publisher: Springer Science & Business Media
ISBN: 8847022347
Category : Medical
Languages : en
Pages : 128
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Book Description
"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.
Author: Alireza Minagar
Publisher: Elsevier
ISBN: 9780123849144
Category : Science
Languages : en
Pages : 540
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Book Description
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities
Author: June Halper, MSN, ANP, FAAN
Publisher: Demos Medical Publishing
ISBN: 1935281259
Category : Health & Fitness
Languages : en
Pages : 316
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Book Description
According to the National Multiple Sclerosis Society, 15% of MS patients are diagnosed with the progressive form of the disease and experience symptoms such as tremor, poor coordination, difficulty walking, and other problems from the start. While an additional 50%, of those diagnosed with relapsing-remitting MS, will develop progressive MS within 10 years. Living with Multiple Sclerosis: Overcoming the Challenges, 2nd Edition is written for people who have been diagnosed with the progressive form of multiple sclerosis. It focuses on the newest advances in managing worsening symptoms and offers hope to MS patients facing the future. This concise and practical overview educates patients about diagnosis, disease-modifying therapies, managing difficult symptoms, and coping strategies. Other topics include: Top Ten Questions about Progressive MS Can Progressive MS be Treated? Vocational and Legal Issues A Glimpse into the Future This encouraging and informative book will be a welcome addition to any patient, healthcare professional, or institutional library.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309072859
Category : Medical
Languages : en
Pages : 457
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Book Description
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Author: Hiroshi Mitoma
Publisher: Springer
ISBN: 3030195155
Category : Medical
Languages : en
Pages : 822
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Book Description
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Author: Patrick A. Lewis
Publisher: Academic Press
ISBN: 0128110708
Category : Science
Languages : en
Pages : 274
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Book Description
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
Author: Julie Stachowiak, PhD
Publisher: Demos Medical Publishing
ISBN: 9781935281726
Category : Health & Fitness
Languages : en
Pages : 173
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Book Description
An empowering guide for increasing your quality of life, navigating challenges, and embracing opportunities Julie Stachowiak, PhD is the About.com Guide to Multiple Sclerosis. As an epidemiologist who is also a person living with MS, Julie has an in-depthunderstanding about the scientific developments around MS and the personal side of living with a chronic illness. In the Multiple Sclerosis Manifesto, Julie shows you how to create your own personal MS manifesto and provides practical tools and reassurance to help you ìget betterî in your life, from optimizing medical care and managing symptoms, to strengthening relationships, dealing with emotions, and embracing activism. Committed to making the hard parts easier and the good parts last longer, Julie show you how to figure out what you need, identify opportunities, understand challenges, and get your needs met. With the Multiple Sclerosis Manifesto, youíll know how to: Create your personal mission statement Protect yourself by learning more about medications you are currently taking or considering to take Determine what you want in a doctor and how to evaluate the doctor you have Celebrate your successesóand why itís essential that you do Make disclosing your MS status to friends, family and others easier Find a support group
Author: Alastair Wilkins
Publisher: Springer
ISBN: 9783319881324
Category : Medical
Languages : en
Pages : 0
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Book Description
This revised, updated second edition draws together the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. New additions to the second edition include a description of clinical scales used to determine levels of disability; recent trials specifically directed at reducing disease progression; rehabilitation; and an in depth discussion of the similarities and differences between primary and secondary multiple sclerosis. The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which have been and will be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail. Progressive Multiple Sclerosis, Second Edition is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.
Author: M. Filippi
Publisher: Springer Science & Business Media
ISBN: 8847003911
Category : Medical
Languages : en
Pages : 236
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Book Description
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
