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Author: Neal G. Anderson
Publisher: Academic Press
ISBN: 0123865387
Category : Science
Languages : en
Pages : 489
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Book Description
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Author: Neal G. Anderson
Publisher: Academic Press
ISBN: 0123865387
Category : Science
Languages : en
Pages : 489
Get Book
Book Description
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Author: Neal G. Anderson
Publisher: Academic Press
ISBN: 0123865379
Category : Business & Economics
Languages : en
Pages : 489
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Book Description
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Author: Neal G. Anderson
Publisher: Academic Press
ISBN: 9781483299778
Category : Science
Languages : en
Pages : 354
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Book Description
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes
Author: Sophie Laws
Publisher: SAGE
ISBN: 9780761973270
Category : Political Science
Languages : en
Pages : 500
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Book Description
`[Research for Development] is well-written and, at every stage, is well-documented with practical examples. The simplicity with which it is written adds to its value in that non-professional persons get well-aquainted with the research process. Every chapter in the book ends with highlighting of the main points made in that chapter... A further strength of the book is the inclusion of an appendix with a list of websites that deal with issues in the area of development research... the simplicity of its organization and message should appeal to people/researchers across disciplines' - Pakistan Development Review `Research for Development achieves the near impossible: it provides vast quantities of useful guidance for almost anyone involved in research for development regardless of the size of your research project or your role within that project' - Arvac Bulletin `Written by professional researchers, this immensely practical book provides development workers with a more research-oriented point of view, so that they can avoid mistakes in the design of programmes. It will also help them to understand people's needs and respond accordingly' - The Asian Age `It is a beautiful and comprehensive compilation giving scores of instances that prove the essentiality if carrying out a survey of a particular locality for bringing about a change there' - Rafique Jalal, DAWN This book provides a comprehensive introduction and handbook for undertaking and managing research in development. It is designed to provide both a quick reference manual and an indispensable learning tool for all students, researchers and practitioners engaged in development work. The text is divided into two parts: Managing research for development, and Doing research for development. Together the two parts review the complete research process from outlining the essential role and purpose of research, highlighting specific issues to development research, to demonstrating how to evaluate and secure the best results from subsequent research projects. The book includes: an overview of different types of research in development work; practical steps to writing a brief and managing research; practical steps to evaluating and promoting research findings; step by step guides to getting started and choosing a research method; detailed guidelines to seven key research techniques; examples, exercises, summaries and checklists; and glossary and guides to additional resources and packages Drawing on considerable hands-on experience, Research for Development will be an essential companion and invaluable tool for anyone engaged in contemporary development research, development work and development studies.
Author: Tricia Striano
Publisher: Guilford Publications
ISBN: 1462524435
Category : Medical
Languages : en
Pages : 192
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Book Description
Addressing practical issues rarely covered in methods texts, this user-friendly, jargon-free book helps students and beginning researchers plan infant and child development studies and get them done. The author provides step-by-step guidance for getting involved in a developmental laboratory and crafting effective research questions and proposals. Tips on recruiting study participants cover access issues--such as how to overcome language and cultural barriers--and include helpful sample scripts. The book offers time management strategies, pointers for organizing and communicating data, and a roadmap of the journal publication process, complete with an annotated sample article. Numerous concrete examples, checklists, worksheets, and exercises are featured. Reproducible forms can be downloaded and printed in a convenient 8 1/2" x 11" size. Pedagogical Features: *Chapter subheadings written as questions to help students quickly find the answers they need. *Boxed key tips and checklists for managing each phase of a study. *Exercises that build core research skills. *Annotated sample journal article with commentary on the writing and publication process.
Author: Stéphane Caron
Publisher: John Wiley & Sons
ISBN: 1119448859
Category : Science
Languages : de
Pages : 850
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Book Description
This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale
Author: Stéphane Caron
Publisher: John Wiley & Sons
ISBN: 1118093569
Category : Science
Languages : en
Pages : 870
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Book Description
A hands-on guide to assist in the planning and execution of synthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be very challenging to identify optimal methods for synthetic transformations that perform as well in real-world manufacturing processes as they do in the laboratory. This detailed and accessible guide attempts to address this vexing issue and deliver proven methodologies practicing synthetic chemists will find valuable for identifying reaction conditions that work reliably over the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning and executing chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond the boundaries of process chemistry groups, such as the synthetic routes of selected contemporary pharmaceutical drugs and practical solvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions, eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages and disadvantages of the methodology, and techniques for achieving laboratory success Incorporating such an extraordinary wealth of information on organic chemistry and its related fields into one complete volume distinguishes Practical Synthetic Organic Chemistry as an incomparable desktop reference for professionals and an invaluable study aid for students.
Author: Daria Mochly-Rosen
Publisher: Springer Science & Business Media
ISBN: 3319022016
Category : Medical
Languages : en
Pages : 176
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Book Description
"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review from Nature Chemical Biology Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest. Each chapter broadly discusses an important topic in drug development, from preclinical work in assay design through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest. "I would actually welcome it if this book’s intended audience were broadened even more. Younger scientists starting out in the drug industry would benefit from reading it and getting some early exposure to parts of the process that they’ll eventually have to understand. Journalists covering the industry (especially the small startup companies) will find this book a good reality check for many an over-hopeful press release. Even advanced investors who might want to know what really happens in the labs will find information here that might otherwise be difficult to track down in such a concentrated form."
Author: Valerie Maholmes
Publisher: Psychology Press
ISBN: 1136988785
Category : Psychology
Languages : en
Pages : 340
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Book Description
Developed for an NIH training institute, this volume is organized around the most frequently asked questions by researchers starting their careers in applied research in child and adolescent development. With contributions from the leading scholars in the field, actual research experiences highlight the challenges one faces in conducting such research. The techniques and theoretical frameworks most suitable for guiding the applied research process are reviewed along with related ethical and cultural considerations. Each chapter features the authors’ introduction to their own careers in applied research. Also included are practical tips, case studies, and sidebars featuring frequently asked questions. This practical resource provides tips on how to: Modify the most frequently used methodological techniques while maintaining the integrity of the data Manage the unpredictable nature of real world research Frame community relevant research questions in an academically acceptable way Secure funding to conduct applied research Disseminate the research results so as to have the greatest impact on policy and practice. The book opens with the most frequently asked questions, tips on getting started in an applied research career, and an overview of and theoretical framework for generating applied developmental research ideas. Section 2 focuses on research designs including the most frequently used methodological and measurement techniques and tips on how to modify them to applied settings. Ethical challenges and cultural issues in working with special populations are also addressed. Section 3 focuses on conducting applied research in school, community, and clinical settings with an emphasis on the challenges encountered when conducting actual research as opposed to the more controlled settings taught in a classroom. Guidelines for protecting the populations involved in the study and strategies for recruiting and retaining participants are also addressed. The book concludes with strategies for disseminating research findings so as to have the greatest impact on policy and practice, for publishing research, and for securing funding. Intended as a practical guide, this book is ideal for those just starting their careers in applied research, for students preparing their dissertations, and for the faculty who prepare these students. The book’s accessible approach also appeals to researchers in the behavioral, social, and health sciences, education, and those in government and industry.
Author: Terry Elizabeth Hedrick
Publisher: SAGE Publications
ISBN: 1506319440
Category : Social Science
Languages : en
Pages : 193
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Book Description
"The Terry E. Hedrick, Leonard Bickman, and Debra J. Rog text provides a framework for designing research that is adaptable to almost any applied setting and constantly reiterates the need for establishing and maintaining credibility with the client at each level of the research process. Although the applied research book is a practical guide, suitable to accompany any thorough applied design textbook, it does a comprehensive job of presenting the distinction between basic and applied research. It introduces many topics found in the general methodology textbooks. This overlap will help students to feel comfortable in using the general skills in a more specific and complex manner." --Contemporary Psychology "For researchers needing to know how to plan and design applied research projects, Applied Research Design will be a most welcome publication. . . . The writing is clear and concise, graphics are utilized helpfully, and this book will be much appreciated by beginning social scientists who are serious but uncertain about the methodologies possible for doing applied research." --Academic Library Book Review Aimed at helping researchers and students make the transition from the classroom and the laboratory to the "real" world, the authors reveal pitfalls to avoid and strategies to undertake in order to overcome obstacles in the design and planning of applied research. Applied Research Design focuses on refining research questions when actual events force deviations from the original analysis. To accomplish this, the authors discuss how to study and monitor program implementation, statistical power analysis, and how to assess the human and material resources needed to conduct an applied research design to facilitate the management of data collection, analysis, and interpretation. Appropriate for professionals and researchers who have had some previous exposure to research methods, this book will enable the development of research strategies that are credible, useful, and--more important--feasible.
