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Author: Xinguo Jiang
Publisher: Academic Press
ISBN: 0128046201
Category : Medical
Languages : en
Pages : 358
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Book Description
Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials. Presents a thorough discussion of the most common nanoparticles in the brain and their neurotoxicology Includes the most common nanoparticles, their applications, and mechanisms Provides one of the first books to focus on nanomedicine and neurotoxicity
Author: Xinguo Jiang
Publisher: Academic Press
ISBN: 0128046201
Category : Medical
Languages : en
Pages : 358
Get Book
Book Description
Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials. Presents a thorough discussion of the most common nanoparticles in the brain and their neurotoxicology Includes the most common nanoparticles, their applications, and mechanisms Provides one of the first books to focus on nanomedicine and neurotoxicity
Author: Hemant Kumar Daima
Publisher: CRC Press
ISBN: 1000399915
Category : Medical
Languages : en
Pages : 494
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Book Description
The field of nanomedicine has risen quickly due to the increasing number of designer-made nanomaterials. These nanomaterials have the potential to manage diseases and change the way medicine is currently studied. However, the increased practice of using nanomaterials has shed light on how many concepts of nanomedicine and nanotoxicity have been overlooked. Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications addresses the existing gaps between nanomedicine and nanotoxicity. This book also brings together up-to-date knowledge on advances toward safe-by-design nanomaterials and existing toxicity challenges. This book delivers a comprehensive coverage in the field with fundamental understanding, serving as a platform to convey essential concepts of nanotoxicology and how these concepts can be employed to develop advanced nanomaterials for a range of biomedical applications. This book is an effort to answer some of the thoughtful nanotoxicological complications and their auspicious probable solutions with new approaches and careful toxicity assessment. Key Features: Reveals novel nanoscale approaches, toxicity assessment, and biomedical applications Includes importance of nanotoxicity concepts in developing smart nanomaterials Highlights unique contributions and "A to Z" aspects on the state-of-the-art from global leaders Offers a complete package to learn fundamentals with recommendations on nanomaterials toxicity and safe-by-design nanomedicines Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications illuminates the high potential of many innovative nanomaterials, ultimately demonstrating them to be promising substitutes for available therapies that can be effectively used in fighting a myriad of biomedical complications. Further, this book reports legal, ethical, safety, and regulatory issues associated with nanomaterials, which have often been neglected, if not overlooked in literature and limiting clinical translation at nanoscale level. It will equip readers with cutting-edge knowledge of promising developments in nanomedicine and nanotoxicology, along with potential future prospects.
Author: Shyamasree Ghosh
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311057909X
Category : Science
Languages : en
Pages : 288
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Book Description
This monograph summarizes the current knowledge on potential health hazards induced by nanomaterials from different sources and sort such as food, drugs and silver nanoparticles. Methods to assess toxicity as well as known effects on the genome, neuronal and respiratory system are discussed. Besides the impact on human and animal life the books also addresses aquatic toxicity.
Author: Diana Boraschi
Publisher: Academic Press
ISBN: 0124079210
Category : Medical
Languages : en
Pages : 138
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Book Description
Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system
Author: Mahendra Rai
Publisher: John Wiley & Sons
ISBN: 1119769868
Category : Science
Languages : en
Pages : 452
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Book Description
NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.
Author: Nancy A. Monteiro-Riviere
Publisher: CRC Press
ISBN: 1482203871
Category : Medical
Languages : en
Pages : 516
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Book Description
Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines. Topics include The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies A roadmap for future research The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.
Author: Bengt Fadeel
Publisher: CRC Press
ISBN: 9814463361
Category : Medical
Languages : en
Pages : 565
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Book Description
The rapidly evolving field of nanomedicine refers to the clinical application of nanotechnologies. However, as with all new technologies, there are ethical, safety, and regulatory issues. This handbook, written by leading international experts, provides a meticulous overview of the state of the art of safety assessment of nanomaterials (nanotoxicology) in the context of their application in nanomedicine. The volume includes a historical perspective on the development of nanomedicine and its regulation, and a personal view of the future of (nano)medicine by Patrick Hunziker, president of the European Society of Nanomedicine. Ethical considerations in relation to nanomedicine are discussed. There are a series of chapters on organ-specific toxicities of nanomaterials, including pulmonary and cardiovascular toxicity, neurotoxicity, dermatotoxicity, and reproductive toxicity, as well as a discussion on immunotoxicity and genotoxicity. The importance of a thorough characterization of physicochemical properties of nanomaterials is emphasized. The handbook also contains a critical discussion on the applicability of in vitro versus in vivo methods and models for nanosafety assessment, along with an introduction to mathematical modeling approaches with a view to a predictive toxicology of nanomaterials. The overall aim is to provide a comprehensive, science-based framework for safety assessment of current and future nanomedicines.
Author: Mehdi Razavi
Publisher: Academic Press
ISBN: 0128202238
Category : Science
Languages : en
Pages : 318
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Book Description
Neural Regenerative Nanomedicine presents novel, significant, experimental results relating to nanoscience and nanotechnology in neural regeneration. As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration. Chapters focus on stem cell biology to advance medical therapies for devastating disorders, the complex, delicate structures that make up the nervous system, and neurodegenerative diseases that cause progressive deterioration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis and multiple system atrophy. Presents a multidisciplinary focus on all research areas surrounding the applications of nanotechnology in neural regeneration Provides a guide for physician and scientists, including necessary expertise for bioengineers, materials engineers, those in biomaterials and nanoengineering, stem cell biologists, and chemists Covers many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, neural regenerative medicine, and nanomedicine
Author: Xue Xue
Publisher: Springer Nature
ISBN: 9811387311
Category : Science
Languages : en
Pages : 313
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Book Description
This book provides an overview of the current applications of nanomaterials in brain diseases, and introduces several novel nanomaterials that have excellent potential in this field. During the last two decades, nanotechnology had matured significantly as it has transitioned from a bench-top science to an applied technology. However, the application of nanomaterials in basic and clinical neuroscience is still at an early stage, and understanding how the intrinsic properties of nanomaterials translate to complex biological responses is an area of intensive research. Part 1 of the book focuses on the principles and strategies of nanomedicine in the brain diseases, while part 2 examines the applications of promising nanomaterials for therapy and diagnosis in the brain. Together they offer a comprehensive picture of advances in nanotechnology and their successful use in treating brain diseases in the past 20 years.
Author: Karthikeyan Subramani
Publisher: William Andrew
ISBN: 1455778575
Category : Technology & Engineering
Languages : en
Pages : 412
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Book Description
New nanomaterials are leading to a range of emerging dental treatments that utilize more biomimetic materials that more closely duplicate natural tooth structure (or bone, in the case of implants). The use of nanostructures that will work in harmony with the body’s own regenerative processes (eg, to restore tooth structure or alveolar bone) are moving into clinical practice. This book brings together an international team of experts from the fields of nanomaterials, biomedical engineering and dentistry, to cover the new materials and techniques with potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region. New dental nanotechnologies include the use of advanced inorganic and organic materials, smart and biomimetic materials, tissue engineering and drug delivery strategies. Book prepared by an interdisciplinary and international group of bio-nanomaterial scientists and dental/oral biomedical researchers Comprehensive professional reference for the subject covering materials fabrication and use of materials for all major diagnostic and therapeutic dental applications – repair,restoration, regeneration, implants and prevention Book focuses in depth on the materials manufacturing processes involved with emphasis on pre-clinical and clinical applications, use and biocompatibility
