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Author: Daria Riva
Publisher: John Libbey Eurotext
ISBN: 2742008365
Category : Medical
Languages : en
Pages : 242
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Book Description
Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.
Author: Daria Riva
Publisher: John Libbey Eurotext
ISBN: 2742008365
Category : Medical
Languages : en
Pages : 242
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Book Description
Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.
Author: Michael Fitzgerald
Publisher: BoD – Books on Demand
ISBN: 1838810056
Category : Medical
Languages : en
Pages : 196
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Book Description
Autism spectrum disorder (ASD) is a complex condition that has extreme heterogeneity, which makes it extremely challenging from a diagnostic and etiological point of view. To add to the complexity, ASD typically has co-morbidity and overlap with other conditions outlined in this book, including epilepsy, attention-deficit/hyperactivity disorder (ADHD), and others. This book also examines monocyte cytokine profiles and catecholamines in ASD, genetic studies of autism, treatments, and controversial issues.
Author: Steven O. Moldin
Publisher: CRC Press
ISBN: 1420004204
Category : Science
Languages : en
Pages : 552
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Book Description
Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment. The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.
Author: Margaret L. Bauman
Publisher: JHU Press
ISBN: 9780801880476
Category : Medical
Languages : en
Pages : 428
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Book Description
In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM
Author: Margaret L. Bauman
Publisher: JHU Press
ISBN: 0801880475
Category : Medical
Languages : en
Pages : 419
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Book Description
In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM
Author: Joseph D. Buxbaum
Publisher: Academic Press
ISBN: 012391924X
Category : Medical
Languages : en
Pages : 494
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Book Description
Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available
Author: Roberto Canitano
Publisher: Frontiers Media SA
ISBN: 2889638693
Category :
Languages : en
Pages : 191
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Book Description
Author: Roberto Canitano
Publisher: Frontiers Media SA
ISBN: 2889452662
Category :
Languages : en
Pages : 175
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Book Description
This Research Topic has the aim to fill the gap of the many unresolved scientific issues on Autism Spectrum Disorders (ASD) that are still in need of investigation, Targeted treatments based on the understanding of the underlying pathogenic mechanisms of disease are still lacking. Further research is awaited and should be obtained through a significant effort on experimental treatment trials and neuroscience research. This Topic is divided in two main sections, one covering clinical issues and another on basic neurosciences of Autism Spectrum Disorders. A more detailed description of the contents of the articles is provided in the editorial at the beginning of the issue.
Author: Valerie W Hu
Publisher: World Scientific
ISBN: 9814602175
Category : Medical
Languages : en
Pages : 724
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Book Description
This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD. Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals. Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio. Contents:Dissecting the Genetic Architecture of ASD:Phenotype Definition: A Cornerstone of Autism Research, Diagnosis and Therapy (Valerie W Hu)From Molecular Pathways to ASD Therapy: Insights from Syndromic Forms of Autism (Laura Nicholls, Radhika Ramadas and Irina Voineagu)Language Impairment in Autism Spectrum Disorders (Natalia Rakhlin and Elena L Grigorenko)Whole Genome Sequencing in Autism: Clinical Translation (Ryan K C Yuen and Stephen W Scherer)The Impact of Integrative Unconventional Data Analysis Approaches on Advancing Autism Genetics Research (Zohreh Talebizadeh and Ayten Shah)Construction of a Genetic Classifier for ASD Using Gene Pathway Analysis (Gursharan Chana, Renee Testa, Piers Gillett, Daniel Williams, Chad A Bousman, Daniela Zantomio, Ian P Everall, Christos Pantelis and Efstratios Skafidas)Gene Dysregulation in ASD: From Transcription to Translation:Genome-Wide Expression Studies of Blood and Lymphoblastoid Cell Lines in Autism Spectrum Disorders (Boryana Stamova and Frank R Sharp)Searching in the “Dark”: Non-Coding RNA as a New Avenue of Autism Research (Tewarit Sarachana and Valerie W Hu)Targeting Noncoding RNA for Treatment of Autism Spectrum Disorders (Jessica DeWitt and Daniel B Campbell)A-to-I RNA Editing in Autism Spectrum Disorder (Alal Eran, Isaac S Kohane and Louis M Kunkel)Translational Control of Autism and Fragile-X Syndrome (Christos G Gkogkas, Argel Aguilar-Valles, Arkady Khoutorsky and Nahum Sonenberg)Epigenetic, Environmental, and Physiological Contributions to ASD:Epigenetics in Autism (Matthew Ginsberg and Marvin Natowicz)The Epigenetics of Autism — Running Beyond the Bases (Simon G Gregory)Genes and Environment in Autism Spectrum Disorders: An Integrated Perspective (Kelly M Bakulski, Alison B Singer and M Daniele Fallin)The Potential Brain Drain from Environmental Exposures on the Methylome and Genome Across Generations (Janine M LaSalle and Keith W Dunaway)Oxidative Stress and Mitochondrial Dysfunction in ASDs (Feng Gu, Ved Chauhan and Abha Chauhan)Maternal Autoantibodies in Autism Spectrum Disorder (Karen L Jones and Judy Van de Water)Why is Autism More Common in Males? (Simon Baron-Cohen, Michael V Lombardo, Bonnie Auyeung, Emma Ashwin, Bhismadev Chakrabarti and Rebecca Knickmeyer)Moving Towards Personalized Treatment of ASD and Lifespan Issues:Future Directions in Psychopharmacology of Autism Spectrum Disorder (Deepali Mankad and Evdokia Anagnostou)Medical Co-Morbidities in Autism: Clues to Underlying Biological Mechanisms and/or Diagnostic Subtypes? (Margaret L Bauman)Translational Implications of a Whole-Body Approach to Brain Health in Autism: How Transduction Between Metabolism and Electrophysiology Points to Mechanisms for Neuroplasticity (Martha R Herbert)Achieving Optimal Outcomes in Autism: Treating Potentially Reversible Conditions Associated with Autism Spectrum Disorder (Richard E Frye and Daniel A Rossignol)Transcranial Magnetic Stimulation: Application in Autism Treatment (Manuel F Casanova and Estate M Sokhadze)Music Therapy: Personalized Interventions for Individuals with Autism Spectrum Disorder (Petra Kern)The Contributions of Art Therapy in Treatment, Assessment, and Research with People Who have Autism Spectrum Disorders (Donna Betts, Rebecca Harmer and Gabriela Schmulevich)Shifting Paradigms: An Examination of Our Understanding of Adult Autism (Rhonda J Greenhaw) Readership: Established investigators and students engaged in autism research; also the general population, especially families of individuals affected by ASD and their professional caregivers. Key Features:This book presents a prospective look forward at autism research in multiple rapidly evolving areas, thus helping to provide focus and directions for future studiesThis book provides perspectives on what translational outcomes (e.g., novel and targeted therapeutics) can be anticipated from such studiesStrong focus on patient-centered researchKeywords:Autism Spectrum Disorders;Genetics;Genomics;Transciptome;Gene Regulation;Epigenetics;Noncoding RNA;RNA Editing;Gene-Environment Interactions;Sex Bias in ASD;Metabolic Dysfunction;Novel Therapeutics;Art Therapy;Music Therapy;Adult Population
Author: Martin J. Lubetsky
Publisher: OUP USA
ISBN: 0199753857
Category : Medical
Languages : en
Pages : 355
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Book Description
Autism Spectrum Disorder of the Pittsburgh Pocket Psychiatry Series highlights current key topics for this developmental neurobiological disorder: early identification and diagnosis; medical, psychiatric, behavioral, social, educational and language evaluations and treatment approaches; genetics and neurobiology; and transition-age and adult services. This book incorporates practical clinical knowledge within a didactic framework to provide a comprehensive overview of Autism Spectrum Disorder (ASD) across the lifespan.
