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Author: Walter J. Gehring
Publisher: Yale University Press
ISBN: 9780300074093
Category : Science
Languages : en
Pages : 270
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Book Description
In this fascinating book, one of the world's most eminent developmental biologists discusses some of the exciting new insights into how genes control development. Walter Gehring describes in vivid detail his essential contributions to the landmark discovery of the homeobox, a characteristic DNA segment found in the genes of all higher organisms from the fruitfly to humans, and he explains how this has provided the key to our modern understanding of development and evolution. The book thus becomes not only a lucid discussion of genetics but also an engaging description of the art of scientific investigation. Gehring begins his story by looking at the work of the many researchers who laid the foundation for the fields of molecular, cellular, and developmental biology, providing insightful vignettes of past and present investigators. He then describes his laboratory's hunt for the gene that caused odd mutations in the fruitfly--in which, for example, antennae on the head were transformed into legs. He explains that researchers eventually found that the same master control genes that dictate the body plan in flies also pattern human bodies, limbs, hands, heart, and brain. And he illustrates the universality of the genetic control of development by describing the development of the eye; eyes as different as those of humans, squids, and flies, he shows, develop under the same master control gene.
Author: Walter J. Gehring
Publisher: Yale University Press
ISBN: 9780300074093
Category : Science
Languages : en
Pages : 270
Get Book
Book Description
In this fascinating book, one of the world's most eminent developmental biologists discusses some of the exciting new insights into how genes control development. Walter Gehring describes in vivid detail his essential contributions to the landmark discovery of the homeobox, a characteristic DNA segment found in the genes of all higher organisms from the fruitfly to humans, and he explains how this has provided the key to our modern understanding of development and evolution. The book thus becomes not only a lucid discussion of genetics but also an engaging description of the art of scientific investigation. Gehring begins his story by looking at the work of the many researchers who laid the foundation for the fields of molecular, cellular, and developmental biology, providing insightful vignettes of past and present investigators. He then describes his laboratory's hunt for the gene that caused odd mutations in the fruitfly--in which, for example, antennae on the head were transformed into legs. He explains that researchers eventually found that the same master control genes that dictate the body plan in flies also pattern human bodies, limbs, hands, heart, and brain. And he illustrates the universality of the genetic control of development by describing the development of the eye; eyes as different as those of humans, squids, and flies, he shows, develop under the same master control gene.
Author: Isabelle Peter
Publisher: Academic Press
ISBN: 0124047467
Category : Science
Languages : en
Pages : 460
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Book Description
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Author: Eric H. Davidson
Publisher: Elsevier
ISBN: 9780080455570
Category : Science
Languages : en
Pages : 304
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Book Description
Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams
Author: Alessandro Minelli
Publisher: Princeton University Press
ISBN: 9780691135687
Category : Science
Languages : en
Pages : 252
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Book Description
What comes first, form or function? Evolutionary developmental biology (or "evo-devo") answers this fundamental question by showing how evolution controls the development of organisms. Alessandro Minelli takes an in-depth and comprehensive look at the history and key issues of evo-devo, focusing on the innovative ways animal organisms evolve through competition and cooperation. Minelli provides a complete overview of conceptual developments--from the fierce nineteenth-century debates between the French biologists Geoffroy and Cuvier, who fought over questions of form versus function--to modern theories of how genes dictate body formation. The book's wide-ranging topics include expression patterns of genes, developmental bias, the role of developmental genes, and genetic determinism. Drawing from diverse examples, such as the anatomy of butterflies, giraffes, Siamese twins, and corals, Minelli extends and reformulates important concepts from development, evolution, and the interplay between the two.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Peter J. Beurton
Publisher: Cambridge University Press
ISBN: 0521771870
Category : Philosophy
Languages : en
Pages : 405
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Book Description
Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology.
Author: Charles J. Epstein
Publisher: Oxford University Press, USA
ISBN: 019514502X
Category : Medical
Languages : en
Pages : 1110
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Book Description
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Author: Antonio Lima-de-Faria
Publisher: Springer Science & Business Media
ISBN: 3642253016
Category : Science
Languages : en
Pages : 171
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Book Description
After having read this book you will never see birds in the same way again. The unexpected patterns displayed by a bird’s body have been seen as bizarre events that demanded little attention or were described as ‘amazing curiosities’. None of these surprising features seem to be fortuitous. They appear to be an integral part of a rigid order and a coherent geometry, which is directed by simple gene interactions and molecular cascades occurring at various cellular levels, and at different times, during the organism’s development. A novel geometry unfolds in front of your eyes, giving the body configurations another meaning. Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund University, Lund, Sweden. This is his sixth book dealing with the molecular organization of the chromosome and its implications for the understanding of the mechanisms responsible for biological evolution.
Author: Kevin Moses
Publisher: Springer Science & Business Media
ISBN: 9783540425908
Category : Medical
Languages : en
Pages : 296
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Book Description
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Author: Richard Burian
Publisher: Cambridge University Press
ISBN: 9780521545280
Category : Medical
Languages : en
Pages : 292
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Book Description
These essays examine the developments in three fundamental biological disciplines--embryology, evolutionary biology, and genetics. These disciplines were in conflict for much of the 20th century and the essays in this collection examine key methodological problems within these disciplines and the difficulties faced in overcoming the conflicts between them. Burian skillfully weaves together historical appreciation of the settings within which scientists work, substantial knowledge of the biological problems at stake and the methodological and philosophical issues faced in integrating biological knowledge drawn from disparate sources.
