Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
ISBN:
Category : Medical
Languages : en
Pages : 692
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Book Description
Evaluates evidence for an increased risk of cancer in women using combined oral contraceptives, progestogen-only hormonal contraceptives, post-menopausal estrogen therapy, and post-menopausal estrogen-progestogen therapy. Although the carcinogenicity of these preparations has been extensively investigated, the book stresses the many complex methodological issues that must be considered when interpreting findings and weighing results. Evidence of an association between use of these preparations and positive effects on health, including a reduced risk of some cancers, is also critically assessed. The first and most extensive monograph evaluates evidence of an association between the use of combined oral contraceptives and cancer at nine sites. Concerning breast cancer, the evaluation concludes that, even if the association is causal, the excess risk for breast cancer associated with patterns of use that are typical today is very small. Studies of predominantly high-dose preparations found an increased risk of hepatocellular carcinoma in the absence of hepatitis viruses. Citing these findings, the evaluation concludes that there is sufficient evidence in humans for the carcinogenicity of combined oral contraceptives. The evaluation also found sufficient evidence for the carcinogenicity of some, but not all, combined preparations in animals. Combined oral contraceptives were classified as carcinogenic to humans. The evaluation also cites conclusive evidence that these agents have a protective effect against cancers of the ovary and endometrium. Progestogen-only contraceptives are evaluated in the second monograph, which considers the association with cancer at six sites. The evaluation found no evidence of an increased risk for breast cancer. Although the evaluation found sufficient evidence in animals for the carcinogenicity of medroxyprogesterone acetate, evidence for the carcinogenicity of progestogen-only contraceptives in humans was judged inadequate. Progestogen-only contraceptives were classified as possibly carcinogenic to humans. The third monograph, on post-menopausal estrogen therapy, considers evidence of an association with cancer at eight sites. Findings from a large number of epidemiological studies indicate a small increase in the risk of breast cancer in women who have used these preparations for five years or more. Studies consistently show an association between use of post-menopausal estrogen therapy and an increased risk for endometrial cancer. Data on the association with other cancers were either inconclusive or suggested no effect on risk. The evaluation concludes that post-menopausal estrogen therapy is carcinogenic to humans. The final monograph evaluates the association between the use of post-menopausal estrogen-progestogen therapy and cancer at four sites. The evaluation of limited data on breast cancer found an increased relative risk observed with long-term use. Data were judged insufficient to assess the effects of past use and of different progestogen compounds, doses, and treatment schedules. For endometrial cancer, the evaluation found an increase in risk relative to non-users when the progestogen was added to the cycle for 10 days or fewer. Post-menopausal estrogen-progestogen therapy was classified as possibly carcinogenic to humans. Concerning post-menopausal therapy in general, the book notes that evidence of carcinogenic risks must be placed in perspective of potential benefits. The prevention of osteoporotic fractures is cited as the best-established benefit. Evidence also suggests that estrogen prevents heart disease and may prevent memory loss and dementia.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
ISBN: 9283212916
Category : Medical
Languages : en
Pages : 544
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Book Description
Oral contraceptives for family planning worldwide have revolutionized the reproductive lives of millions of women since their introduction in the 1960s. Later on, a variety of side-effects including cardiovascular diseases was recognized. In response to these concerns, new generations of combined oral contraceptives were developed that featured lower dose of estrogen and newer, more potent progestogens. The effectiveness and ease of use of combined hormonal contraceptives suggest that they will continue to be used to a significant extent in the future. This ninety-first volume of IARC Monograp.
Author: Hilary O. D. Critchley
Publisher:
ISBN: 9781904752110
Category : Menopause
Languages : en
Pages : 364
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Book Description
Author: A.R. Genazzani
Publisher: CRC Press
ISBN: 9781842140383
Category : Medical
Languages : en
Pages : 208
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Book Description
This is a high-level, clinical reference by world-class specialists on the efficacy of hormone replacement therapy for the primary prevention of cardiovascular risk in postmenopausal women. Specific chapters cover pulsed estrogen therapy with Aerodiol and cardiovascular risk assessment in postmenopausal hormone replacement therapies such as Livial (tibolone). This volume is based on the formal presentations and subsequent discussions that took place at the International Menopause Society specially convened Expert Workshop on Hormone Replacement Therapy and Cardiovascular Disease, London, UK, October 13-16, 2000.
Author:
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 136
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Book Description
An information guide to information on the subject of menopause.
Author: José Biller
Publisher: Newnes
ISBN: 0702044342
Category : Medical
Languages : en
Pages : 816
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Book Description
Systemic disease involves several parts of the body or the complete system. This comprehensive reference focuses on the specific neurologic aspects of systemic disease. Part 3 includes coverage of oncologic disorders, organ transplantation, infectious diseases, tropical neurology, pregnancy, neuroanesthesia and other diseases and disorders. Each chapter provides a complete introduction to the neurologic aspect and provides the best known diagnostic and treatment practices. The collection will be a valuable and trusted resource for clinical neurologists, research neurologists and neuroscientists and general medical professionals as a first stop for a comprehensive and focused review of the state of the art for understanding the neurologic impact of each covered disease. A comprehensive introduction and overview of the neurologic aspects of systemic disease Part 3 covers of oncologic disorders, organ transplantation, infectious diseases, tropical neurology, pregnancy, neuroanesthesia and other diseases and disorders Each chapter focuses on the neurologic aspects related to a specific disease presentation
Author: L. R. Sitruk-Ware
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 328
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Book Description
Specialists of several disciplines address most of the controversies still prevailing on menopause and its related disorders as well as its therapeutic aspects. The contributed chapters are organized in sections dealing with considerations pertaining to the untreated menopause, the treated menopause
Author: M.I. Whitehead
Publisher: CRC Press
ISBN: 9781850709749
Category : Medical
Languages : en
Pages : 224
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Book Description
Drawing together many of the world's foremost experts, this book provides clear and specific guidance about the prescription of hormone replacement therapy. It covers prescribing for patients with a wide range of pre-existing diseases. In each instance, expert advice is given with reference to the latest published research. There is also an overview of other key issues affecting the choice of therapy.
Author:
Publisher: World Health Organization
ISBN: 9241563885
Category : Business & Economics
Languages : en
Pages : 130
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Book Description
Medical Eligibility Criteria for Contraceptive Use reviews the medical eligibility criteria for use of contraception, offering guidance on the safety and use of different methods for women and men with specific characteristics or known medical conditions. The recommendations are based on systematic reviews of available clinical and epidemiological research. It is a companion guideline to Selected Practice Recommendations for Contraceptive Use. Together, these documents are intended to be used by policy-makers, program managers, and the scientific community to support national programs in the preparation of service delivery guidelines. The fourth edition of this useful resource supersedes previous editions, and has been fully updated and expanded. It includes over 86 new recommendations and 165 updates to recommendations in the previous edition. Guidance for populations with special needs is now provided, and a new annex details evidence on drug interactions from concomitant use of antiretroviral therapies and hormonal contraceptives. To assist users familiar with the third edition, new and updated recommendations are highlighted. Everyone involved in providing family planning services and contraception should have the fourth edition of Medical Eligibility Criteria for Contraceptive Use at hand.
Author: Rogerio A. Lobo
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 712
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Book Description
Thoroughly updated and substantially expanded, the Second Edition of this volume is the most comprehensive and current text on treatment of the perimenopausal and postmenopausal woman. Coverage encompasses all the major health issues that arise during and after menopause and includes extensive discussions of the risks and benefits of hormone replacement therapy.
