Author: Publisher:
ISBN:
Category : Kinins
Languages : de
Pages : 854
Book Description
Good Research Practice in Non-Clinical Pharmacology and Biomedicine
Author: Anton BespalovPublisher: Springer Nature
ISBN: 3030336565
Category : Cardiology
Languages : en
Pages : 424
Book Description
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Drug Delivery
Author: Binghe WangPublisher: John Wiley & Sons
ISBN: 1118833368
Category : Science
Languages : en
Pages : 740
Book Description
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Concepts and Principles of Pharmacology
Author: James E. BarrettPublisher: Springer Nature
ISBN: 3030353621
Category : Medical
Languages : en
Pages : 466
Book Description
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Adverse Drug Reactions
Author: Jack UetrechtPublisher: Springer Science & Business Media
ISBN: 9783642006630
Category : Medical
Languages : en
Pages : 556
Book Description
This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.
Gastrointestinal Pharmacology
Author: Beverley Greenwood-Van MeerveldPublisher: Springer
ISBN: 3319563602
Category : Medical
Languages : en
Pages : 444
Book Description
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.
Methylxanthines
Author: Bertil B. FredholmPublisher: Springer Science & Business Media
ISBN: 9783642134432
Category : Medical
Languages : en
Pages : 559
Book Description
In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.
Pediatric Clinical Pharmacology
Author: Hannsjörg W. SeyberthPublisher: Springer Science & Business Media
ISBN: 3642201954
Category : Medical
Languages : en
Pages : 385
Book Description
The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.
Drug Transporters
Author: Martin F. FrommPublisher: Springer Science & Business Media
ISBN: 3642145418
Category : Medical
Languages : en
Pages : 454
Book Description
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Handbook of Experimental Pharmacology
Author: Modern Anesthetics
Author: Jürgen SchüttlerPublisher: Springer Science & Business Media
ISBN: 3540748067
Category : Medical
Languages : en
Pages : 498
Book Description
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
