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Author: T. C. McCarthy
Publisher: Orbit
ISBN: 0316179922
Category : Fiction
Languages : en
Pages : 213
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Book Description
Germline (n.) the genetic material contained in a cellular lineage which can be passed to the next generation. Also: secret military program to develop genetically engineered super-soldiers (slang). War is Oscar Wendell's ticket to greatness. A reporter for The Stars and Stripes, he has the only one way pass to the front lines of a brutal war over natural resources buried underneath the icy, mineral rich mountains of Kazakhstan. But war is nothing like he expected. Heavily armored soldiers battle genetically engineered troops hundreds of meters below the surface. The genetics-the germline soldiers-are the key to winning this war, but some inventions can't be un-done. Some technologies can't be put back in the box. Kaz will change everything, not least Oscar himself. Hooked on a dangerous cocktail of adrenaline and drugs, Oscar doesn't find the war, the war finds him.
Author: T. C. McCarthy
Publisher: Orbit
ISBN: 0316179922
Category : Fiction
Languages : en
Pages : 213
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Book Description
Germline (n.) the genetic material contained in a cellular lineage which can be passed to the next generation. Also: secret military program to develop genetically engineered super-soldiers (slang). War is Oscar Wendell's ticket to greatness. A reporter for The Stars and Stripes, he has the only one way pass to the front lines of a brutal war over natural resources buried underneath the icy, mineral rich mountains of Kazakhstan. But war is nothing like he expected. Heavily armored soldiers battle genetically engineered troops hundreds of meters below the surface. The genetics-the germline soldiers-are the key to winning this war, but some inventions can't be un-done. Some technologies can't be put back in the box. Kaz will change everything, not least Oscar himself. Hooked on a dangerous cocktail of adrenaline and drugs, Oscar doesn't find the war, the war finds him.
Author: Nelson Erlick
Publisher: Macmillan
ISBN: 076530094X
Category : Fiction
Languages : en
Pages : 390
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Book Description
Scientist Dr. Kevin Kincaid finds himself at the center of a storm of controversy and murder when he announces he has developed a technique that would allow the introduction of new genes into the germ cells of babies while they are still in the womb, thus eradicating genetic diseases for future generations.
Author: Florence Louise Marlow
Publisher: Morgan & Claypool Publishers
ISBN: 161504051X
Category : Family & Relationships
Languages : en
Pages : 221
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Book Description
Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References
Author: The Royal Society
Publisher: National Academies Press
ISBN: 0309671132
Category : Medical
Languages : en
Pages : 239
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Book Description
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author: Andrea Boggio
Publisher: Cambridge University Press
ISBN: 1108499872
Category : Law
Languages : en
Pages : 681
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Book Description
A survey of the regulation of human germline genome modification in eighteen countries and the emerging international standards.
Author: Steven X. Hou
Publisher: Humana Press
ISBN: 9781617378805
Category : Science
Languages : en
Pages : 0
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Book Description
In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.
Author:
Publisher: Academic Press
ISBN: 9780080584607
Category : Science
Languages : en
Pages : 422
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Book Description
In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. Authors provide easy access to the literature for those who want to pursue topics in greater depth, but reviews are comprehensive so that this book may become a standard reference. Key Features * Comprehensive reviews that, taken together, provide up-to-date coverage of a rapidly moving field * Features new and unpublished information * Integrates research in diverse organisms to present an overview of common threads in mechanisms of meiosis * Includes thoughtful consideration of areas for future investigation
Author: Prateek Sharma
Publisher: John Wiley & Sons
ISBN: 1405171537
Category : Medical
Languages : en
Pages : 312
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Book Description
The leading reference text entirely devoted to this increasinglysignificant condition This text is dedicated to Barrett’s esophagus and providesrecent evidence and current approaches to patient management. Ithas been completely revised, updated and extended to include thelatest research findings and describes how these affect day-to-dayclinical practice. It includes seven new chapters and even more color images thanthe last edition. Each chapter, written by the leadinginternational experts in the field, provides clear, didacticguidance on diagnosis, treatment and management of thiscondition. Barrett’s Espohagus gives an extensive overviewcovering epidemiology, screening, pathology, gastroenterology andsurgery. It looks at the precursor lesions leading to thedevelopment of Barrett’s epithelium, the uniquecharacteristics of Barrett’s esophagus, and the consequencesof malignant degeneration. All aspects of diagnosis, secondaryprevention, multimodality, and medical and surgical treatment areclearly explained. This is a complete guide on the latest thinking on diagnosis andtreatment of Barrett’s esophagus which can be referred toover and over again.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309452880
Category : Medical
Languages : en
Pages : 329
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Book Description
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Author: Roland Dosch
Publisher: Humana
ISBN: 9781071609729
Category :
Languages : en
Pages : 383
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Book Description
