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Author: Ming Tan
Publisher: Wiley
ISBN: 9780470669693
Category : Medical
Languages : en
Pages : 0
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Book Description
Containing the historical and statistical information necessary to choose an analysis method and successful drug combination, Evaluating Synergy provides a systematic introduction of statistical methods for optimally designing and analyzing combination studies in cancer, anti-viral, and other therapeutic areas. This practical guide provides scientists in translational research, data analysts, and statisticians in cancer research with a detailed discussion on the challenging case of three or multi-drug combinations. Numerous examples accompany a presentation that illustrates experimental design considerations for modern drug analysis.
Author: Ming Tan
Publisher: Wiley
ISBN: 9780470669693
Category : Medical
Languages : en
Pages : 0
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Book Description
Containing the historical and statistical information necessary to choose an analysis method and successful drug combination, Evaluating Synergy provides a systematic introduction of statistical methods for optimally designing and analyzing combination studies in cancer, anti-viral, and other therapeutic areas. This practical guide provides scientists in translational research, data analysts, and statisticians in cancer research with a detailed discussion on the challenging case of three or multi-drug combinations. Numerous examples accompany a presentation that illustrates experimental design considerations for modern drug analysis.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264190651
Category :
Languages : en
Pages : 672
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Book Description
This report provides an international comparative analysis and policy advice to countries on how evaluation and assessment arrangements can be embedded within a consistent framework to improve the quality, equity and efficiency of school education.
Author: Ronald J. Tallarida
Publisher: CRC Press
ISBN: 1420036106
Category : Mathematics
Languages : en
Pages : 268
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Book Description
Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few
Author: Stefano Garzella
Publisher: Springer
ISBN: 331940671X
Category : Business & Economics
Languages : en
Pages : 91
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Book Description
This book addresses synergy management, which poses an important challenge for firms, advisors and practitioners involved in mergers and acquisitions (M&A). Synergy plays a key role in M&A contexts, both in the decision-making process and, subsequently, in the integration phase. However, despite the fact that synergy value is commonly regarded as one of the key success factors in M&A, research shows that firms generally fail to achieve the expected synergy. The extant literature is characterized by a lack of comprehensive models of synergy management: the assessment of synergy value remains a “black box” for scholars and practitioners alike. The authors provide a comprehensive framework for synergy management by integrating findings from prior research and various disciplines. The framework highlights the main dimensions of synergy management in mergers and acquisitions, common pitfalls, and new models and tools for avoiding them. As such, the book enriches the M&A literature, offers new insights for scholars, and provides valuable guidelines for practitioners involved in synergy management.
Author: Roberta Kaplow
Publisher: Jones & Bartlett Learning
ISBN: 9780763726010
Category : AACN synergy model for patient care
Languages : en
Pages : 260
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Book Description
An essential reference for nursing students in developing and implementing the competencies necessary in caring for critically ill patients. Includes sample test questions relevant to the model that will assist nursing students in preparing for certification through AACN.
Author: James R. Larson
Publisher: Psychology Press
ISBN: 0805859438
Category : Business & Economics
Languages : en
Pages : 433
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Book Description
This volume critically evaluates more than a century of empirical research on the effectiveness of small, task-performing groups, and offers a fresh look at the costs and benefits of collaborative work arrangements. The central question taken up by this book is whether -- and under what conditions -- interaction among group members leads to better performance than would otherwise be achieved simply by combining the separate efforts of an equal number of people who work independently. This question is considered with respect to a range of tasks (idea-generation, problem solving, judgment, and decision-making) and from several different process perspectives (learning and memory, motivation, and member diversity). As a framework for assessing the empirical literature, the book introduces the concept of 'synergy.' Synergy refers to an objective gain in performance that is attributable to group interaction. Further, it distinguishes between weak and strong synergy, which are performance gains of different magnitude. The book highlights the currently available empirical evidence for both weak and strong synergy, identifies the conditions that seem necessary to produce each, and suggests where the search for synergy might best be directed in the future. The book is at once a high-level introduction to the field, a review of the field's history, and a scholarly critique of the current state-of-the-art. As such, it is essential reading for graduate students, advanced undergraduate students, and researchers interested in group dynamics generally -- and small group performance in particular.
Author: James R. Larson, Jr.
Publisher: Psychology Press
ISBN: 1136950788
Category : Psychology
Languages : en
Pages : 432
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Book Description
This volume critically evaluates more than a century of empirical research on the effectiveness of small, task-performing groups, and offers a fresh look at the costs and benefits of collaborative work arrangements. The central question taken up by this book is whether -- and under what conditions -- interaction among group members leads to better performance than would otherwise be achieved simply by combining the separate efforts of an equal number of people who work independently. This question is considered with respect to a range of tasks (idea-generation, problem solving, judgment, and decision-making) and from several different process perspectives (learning and memory, motivation, and member diversity). As a framework for assessing the empirical literature, the book introduces the concept of 'synergy.' Synergy refers to an objective gain in performance that is attributable to group interaction. Further, it distinguishes between weak and strong synergy, which are performance gains of different magnitude. The book highlights the currently available empirical evidence for both weak and strong synergy, identifies the conditions that seem necessary to produce each, and suggests where the search for synergy might best be directed in the future. The book is at once a high-level introduction to the field, a review of the field's history, and a scholarly critique of the current state-of-the-art. As such, it is essential reading for graduate students, advanced undergraduate students, and researchers interested in group dynamics generally -- and small group performance in particular.
Author: Mark L. Sirower
Publisher: Simon and Schuster
ISBN: 9781439137703
Category : Business & Economics
Languages : en
Pages : 304
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Book Description
With acquisition activity running into the trillions of dollars, the acquisition alternative continues to be the favorite corporate growth strategy of this generation's executives. Unfortunately, creating shareholder value remains the most elusive outcome of these corporate strategies. After decades of research and billions of dollars paid in advisory fees, why do these major decisions continue to destroy value? Building on his groundbreaking research first cited in Business Week, Mark L. Sirower explains how companies often pay too much -- and predictably never realize the promises of increased performance and competitiveness -- in their quest to acquire other companies. Armed with extensive evidence, Sirower destroys the popular notion that the acquisition premium represents potential value. He provides the first formal and functional definition for synergy -- the specific increases in performance beyond those already expected for companies to achieve independently. Sirower's refreshing nuts-and-bolts analysis of the fundamentals behind acquisition performance cuts sharply through the existing folklore surrounding failed acquisitions, such as lack of "strategic fit" or corporate culture problems, and gives managers the tools to avoid predictable losses in acquisition decisions. Using several detailed examples of recent major acquisitions and through his masterful integration and extension of techniques from finance and business strategy, Sirower reveals: The unique business gamble that acquisitions represent The managerial challenges already embedded in current stock prices The competitive conditions that must be met and the organizational cornerstones that must be in place for any possibility of synergy The precise Required Performance Improvements (RPIs) implicitly embedded in acquisition premiums and the reasons why these RPIs normally dwarf realistic performance gains The seductiveness and danger of sophisticated valuation models so often used by advisers The Synergy Trap is the first exposé of its kind to prove that the tendency of managers to succumb to the "up the ante" philosophy in acquisitions often leads to disastrous ends for their shareholders. Sirower shows that companies must meticulously plan -- and account for huge uncertainties -- before deciding to enter the acquisition game. To date, Sirower's work is the most comprehensive and rigorous, yet practical, analysis of the drivers of acquisition performance. This definitive book will become required reading for managers, corporate directors, consultants, investors, bankers, and academics involved in the mergers and acquisitions arena.
Author: Stefan Karenfort
Publisher: BoD – Books on Demand
ISBN: 3844100350
Category : Business & Economics
Languages : en
Pages : 150
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Book Description
The creation of synergy, which is often illustrated as the "2+2=5-effect", is a dominant motive as well as a key success factor for Mergers & Acquisitions (M&A). Inadequate expectations with respect to the synergistic potential can however easily result in an overrated acquisition price. If the planned synergies later fail to materialize, it will be increasingly hard for the acquiring firm to achieve positive value gains for its shareholders. It is therefore vital to obtain a comprehensive understanding of the synergistic potential of a planned M&A project. This issue was addressed with a doctoral thesis investigating the underlying drivers of synergy realization, in particular the concept of business relatedness which describes the similarity of firm attributes, such as product-market presence, resource configuration and supply channel types. Using a quantitative hypothesis-testing survey design, more than 300 M&A consultants worldwide have been invited to evaluate past M&A transactions with respect to their synergistic effects. In contrast to earlier studies, the relatedness of the merging firms is established as a multi-dimensional concept considering various attributes of business relatedness simultaneously. The degree of relatedness is measured using managerial perceptions which is a comparatively new measurement approach transferred from diversification research to the field of M&A. The individual dimensions of relatedness show a different effectiveness concerning synergy realization providing further support to recent contributions which advocate a multi-dimensional conceptualization of business relatedness. The study identifies dimensions of business relatedness and their underlying drivers which are particularly relevant to predictions concerning the synergistic potential. The research project thus makes a valuable contribution to clarify the impact of relatedness on M&A performance and provides important implications for practitioners regarding the eval
Author: James R. Larson, Jr.
Publisher: Psychology Press
ISBN: 113695077X
Category : Psychology
Languages : en
Pages : 433
Get Book
Book Description
This volume critically evaluates more than a century of empirical research on the effectiveness of small, task-performing groups, and offers a fresh look at the costs and benefits of collaborative work arrangements. The central question taken up by this book is whether -- and under what conditions -- interaction among group members leads to better performance than would otherwise be achieved simply by combining the separate efforts of an equal number of people who work independently. This question is considered with respect to a range of tasks (idea-generation, problem solving, judgment, and decision-making) and from several different process perspectives (learning and memory, motivation, and member diversity). As a framework for assessing the empirical literature, the book introduces the concept of 'synergy.' Synergy refers to an objective gain in performance that is attributable to group interaction. Further, it distinguishes between weak and strong synergy, which are performance gains of different magnitude. The book highlights the currently available empirical evidence for both weak and strong synergy, identifies the conditions that seem necessary to produce each, and suggests where the search for synergy might best be directed in the future. The book is at once a high-level introduction to the field, a review of the field's history, and a scholarly critique of the current state-of-the-art. As such, it is essential reading for graduate students, advanced undergraduate students, and researchers interested in group dynamics generally -- and small group performance in particular.
