Effect of Calcium Channel Blockers on the Incidence of Restenosis After Coronary Balloon Angioplasty and on the Progression of Coronary Artery Disease PDF Download
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Author: Joseph Dens
Publisher: Leuven University Press
ISBN: 9789058672988
Category : Calcium
Languages : en
Pages : 172
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Book Description
"Nisoldipine, In-vitro effects of calcium channel blockers in reducing restenosis after balloon angioplasty and in retarding the progression of atherosclerosis, Usefulness of nisoldipine for prevention of restenosis after percutaneous transluminal coronary angioplasty, An updated meta-analysis of calcium channel blockers in the prevention of restenosis after coronary angioplasty, Late angiographic follow-up of dilated coronary lesions, Long-term effects of nioldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study, General Discussion, Final Conclusions and further directions."
Author: Joseph Dens
Publisher: Leuven University Press
ISBN: 9789058672988
Category : Calcium
Languages : en
Pages : 172
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Book Description
"Nisoldipine, In-vitro effects of calcium channel blockers in reducing restenosis after balloon angioplasty and in retarding the progression of atherosclerosis, Usefulness of nisoldipine for prevention of restenosis after percutaneous transluminal coronary angioplasty, An updated meta-analysis of calcium channel blockers in the prevention of restenosis after coronary angioplasty, Late angiographic follow-up of dilated coronary lesions, Long-term effects of nioldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study, General Discussion, Final Conclusions and further directions."
Author: Xiaoshun Liu
Publisher: Leuven University Press
ISBN: 9789058674432
Category : Coronary arteries
Languages : en
Pages : 190
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Book Description
This is a Ph.D. dissertation. Restenosis occurs in 10-50% of patients after PCI, thus remaining a major challenge. Restenosis after PCI is a complex, multifactorial, overlapping wound healing process involving a cascade of cellular and molecular events including platelet activation, inflammatory cell infiltration, smooth muscle cell proliferation, migration and extracellular matrix production. Recent evidence shows that inflammation, matrix metalloproteinases and free oxygen radicals all play a critical role in the restenosis process. Different approaches to prevent restenosis after PCI were studied in this work. Restenosis has been remarkably reduced in the last decade with the introduction of stents. Stents have been optimized regarding their mechanical features, allowing for scaffolding of the plaque and producing an optimal coronary lumen at the end of the procedure. By their metallic nature however, they cause prolonged and chronic inflammation in the vessel wall. Therefore, the long term efficacy remains a concern. In the first study, the author evaluated the long-term follow-up of patients that underwent bare metal stent implantation. The long-term efficacy of this stent was established, and the major adverse cardiac events (MACE) during the long-term follow-up were mainly caused by progression of lesions in other vessels. This study confirmed that implantation of a bare metal stent in an effective treatment modality of atherosclerotic coronary disease. However, in-stent restenosis still results in a failure of this treatment in about 30% of the patients, mostly occurring within the first 6 months.
Author: Karel Talavera Perez
Publisher: Leuven University Press
ISBN: 9789058673824
Category : Calcium channels
Languages : en
Pages : 134
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Book Description
Author: Yanming Huang
Publisher: Leuven University Press
ISBN: 9789058673275
Category :
Languages : en
Pages : 154
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Book Description
"This is a Ph.D. dissertation. Role of Inflammation in the Pathogenesis of Restenosis, Local Drug Delivery Using Drug Eluting Stents, In Vitro Stent Implantation, Optimization of Local Methylprednisolone Delivery to Inhibit Inflammatory Reaction and Neointimal Hyperplasia of Coated Coronary Stents, Cytochalasin Polymer Coated Stents Reduce Neointimal Formation in a Porcine Coronary Model, Long-Term Biocompatibility Evaluation of a Biodegradable Polymer Coated Stent in a Porcine Coronary Stent Model, Methotrexate Loaded SAE-Coated Coronary Stents Reduce Neointimal Hyperplasia in a Porcine Coronary Model, Local Methylprednisolone Delivery Using a Biodivysio Phosphorycholone Coated Drug Delivery Stents Reduces Inflammation and Neointimal Hyperplasia in a Porcine Coronary Stent Model, Stent Based Dexamethasone Delivery: From Pre-Clinical Data to the Stride Trial, General Discussions and Conclusions."
Author: Isabelle Huys
Publisher: Leuven University Press
ISBN: 9789058673534
Category : Science
Languages : en
Pages : 240
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Book Description
"This is a Ph.D. dissertation. Many fundamental processes underlying nerve and muscle excitation, hormone secretion, learning and memory, cell proliferation, sensory transduction and regulation of blood pressure and osmotic balance, are attributed to a div"
Author: Petra De Haes
Publisher: Leuven University Press
ISBN: 9789058674289
Category : Keratinocytes
Languages : en
Pages : 178
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Book Description
This is a Ph.D. dissertation. The skin serves as a protective interface between the body and the noxious environment. Ultraviolet (UV) radiation is one of the most important sources of environmental stress, inducing photochemical changes in the skin that may lead to sunburn, premature skin aging and skin cancer. The skin and UV also play a leading part in the vitamin D endocrine system. When UVB photons strike the epidermis, their energy can be used for the synthesis of vitamin D3. Furthermore, the skin is one of the direct target issues for vitamin D3 action. The close interplay between UV and vitamin D3 production in the skin evokes the possibility of mutual interactions. Contents: Introduction, Aims and Scopes of the Study, Materials and Methods, 1,25D3 Inhibits UVB-Induced Apoptosis and IL-6 Production in Human Keratinocytes, 1,25D3 Protects Human Keratinocytes Against UVB-Induced Damage, Two 14-EPI Analogues of 1,25D3 Protect Human Keratinocytes Against Different UVB Effects, Molecular Pathways Involved in the Anti-Apoptotic Effect of 1,25D3 in Human Keratinocytes, General Discussion and Perspectives.
Author: Nuha El Sharif
Publisher: Leuven University Press
ISBN: 9789058673183
Category :
Languages : en
Pages : 174
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Book Description
![Molecular Modes of Action of 1[alpha], 25-dihydroxyvitamin D3 and Analogs PDF](https://books.google.com/books/content/images/frontcover/zhrsPQ7Z7mkC?fife=w80-h100)
Author: Guy Eelen
Publisher: Leuven University Press
ISBN: 9789058674753
Category : Vitamin D
Languages : en
Pages : 206
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Book Description
Author: Dieter Nuyens
Publisher: Leuven University Press
ISBN: 9789058675309
Category : Genetic disorders
Languages : en
Pages : 142
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Book Description
Author: Sophie Van Cromphaut
Publisher: Leuven University Press
ISBN: 9789058674470
Category : Calcium
Languages : en
Pages : 170
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Book Description
This is a Ph.D. dissertation. The aim of this thesis was to understand the role of 1,25(OH)2D3 and other steroid hormones in the regulation of active duodenal calcium absorption. To achieve this aim, the authors analyzed active duodenal calcium absorption at molecular and functional level. Contents include: Introduction: Calcium, The vitamin D endocrine system, Calcium (re)absorption, Active calcium absorption, vitamin D independent mechanisms; Aims and Scope of the study; Vitamin D dependent active duodenal calcium absorption; Active calcium absorption throughout the female reproductive cycle; The contribution of altered active absorption to the pathogenesis of glucocorticoid-induced bone loss; Discussion; Summary; Perspectives.
