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Author: Alexander Vaiserman
Publisher: Springer
ISBN: 3030249581
Category : Science
Languages : en
Pages : 310
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Book Description
This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.
Author: Alexander Vaiserman
Publisher: Springer
ISBN: 3030249581
Category : Science
Languages : en
Pages : 310
Get Book
Book Description
This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.
Author: Nancy A. Pachana
Publisher: Oxford University Press
ISBN: 0191038466
Category : Psychology
Languages : en
Pages : 144
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Book Description
Ageing is an activity we are familiar with from an early age. In our younger years upcoming birthdays are anticipated with an excitement that somewhat diminishes as the years progress. As we grow older we are bombarded with advice on ways to overcome, thwart, resist, and, on the rare occasion, embrace, one's ageing. Have all human beings from the various historical epochs and cultures viewed aging with this same ambivalence? In this Very Short Introduction Nancy A. Pachana discusses the lifelong dynamic changes in biological, psychological, and social functioning involved in ageing. Increased lifespans in the developed and the developing world have created an urgent need to find ways to enhance our functioning and well-being in the later decades of life, and this need is reflected in policies and action plans addressing our ageing populations from the World Health Organization and the United Nations. Looking to the future, Pachana considers advancements in the provision for our ageing populations, including revolutionary models of nursing home care such as Green House nursing homes in the USA and Small Group Living homes in the Netherlands. She shows that understanding the process of ageing is not only important for individuals, but also for societies and nations, if the full potential of those entering later life is to be realised. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Author: Diana Kuh
Publisher: OUP Oxford
ISBN: 0191008176
Category : Medical
Languages : en
Pages : 288
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Book Description
Healthy ageing has long been a neglected area of epidemiological research as the traditional focus has been on specific chronic diseases of older life. There is a growing consensus from scientists, research funders and policy makers that ageing itself needs to be studied from an interdisciplinary and life course perspective, to inform strategies for reducing the societal and individual costs of an ageing population. A Life Course Approach to Healthy Ageing is a synthesis of life course perspectives in epidemiology and interdisciplinary perspectives in ageing research. It brings together expert investigators of maturing birth cohort and ageing studies, cross-cutting methodologists, and authorities in ageing research and knowledge transfer from across the world in one wide-ranging volume. Contributors discuss how aspects of healthy ageing are conceptualised, defined and measured; relate to each other; change across life; and are influenced by biological, psychological and social factors operating from early life onwards. They identify research gaps, and suggest how evidence from observational studies can be strengthened through improved study design and longitudinal analysis, thereby increasing the research contribution to practice or policy change. The book considers how we might delay or slow down the progressive, generalised impairment of function that occurs at the individual, body system and cellular levels, as people grow older. It also considers the determinants of wellbeing in older people, including personal fulfilment, positive emotions and social relationships. Broad in scope, discussing topics from genetics to psychological and social wellbeing, A Life Course Approach to Healthy Ageing is a key resource for epidemiologists, social scientists, clinicians, public health physicians, policy makers and practitioners with a research interest in healthy ageing.
Author: Stuart Jay Olshansky
Publisher:
ISBN: 9781621820802
Category : MEDICAL
Languages : en
Pages : 0
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Book Description
"Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--
Author: David A. Sinclair
Publisher: Atria Books
ISBN: 1501191977
Category : Science
Languages : en
Pages : 432
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Book Description
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Author: Arthur V. Everitt
Publisher: Springer Science & Business Media
ISBN: 9789048185566
Category : Medical
Languages : en
Pages : 323
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Book Description
Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.
Author: Ma Stephen C Schimpff MD
Publisher: Squire Publishing
ISBN: 9780692064207
Category :
Languages : en
Pages : 202
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Book Description
You can live a long and healthy life. There is no magic pill or Fountain of Youth, but you can achieve it with simple lifestyle modifications: 1. Eating the right foods 2. Getting the right exercise 3. Reducing and managing stress 4. Improving the quality of sleep 5. Eliminating tobacco 6. Remaining intellectually engaged 7. Staying involved socially The advice in Longevity Decoded works-because it puts you in charge of shaping your future. Everyone wants to live a long and healthy life-Longevity Decoded is your roadmap. The seven keys cost nothing, except your time and commitment. Dr. Stephen Schimpff provides you with straightforward advice for achieving and maintaining good health over a long life. Following his seven keys will pay generous returns over the years ahead, and there's a bonus: You'll become a role model and inspiration to your children and grandchildren! "Dr. Schimpff explores the exciting topic of healthy aging. He combines the science of aging with evidence to suggest how each of us influences our personal journey in life. We make choices every day which impact our health. This book will help you understand how those daily choices will influence your life not only today, but as you get older. Begin today to plan for tomorrow." -James (Jim) M. Anders, Jr., CPA, MBA, CGMA, President and Chairman of the Board, National Senior Campuses, Inc., Administrator and Chief Operating Officer, Kennedy Krieger Institute, Inc. "A highly enjoyable and uplifting read written by a physician with uncommon intellect and wisdom. Certainly, we can all benefit from following Dr. Schimpff's prescription for a healthier and more meaningful life." -R. Alan Butler, Chief Executive Office, Erickson Living "Brilliant work by Dr. Stephen Schimpff yet again! Dr. Schimpff has done a systematic analysis of aging and longevity. His uncanny ability to use data and science together makes his suggestions compelling and convincing, while being insightful. Despite being a complete and thorough account for advanced readers, his book is simple enough to understand for a beginner. If there is only one book you want to read on this subject, it should be this one." -Hiren Doshi, CEO, Paragon Private Health, Co-founder and President, OmniActive Health Technologies "As my age cohort heads toward Medicare, like a veritable tsunami of aging boomers, this text ought to be our navigational guide in the storm. We will want yoga on the lawn, rather than a wheelchair in the garden; we will crave gourmet organic meals, not a nursing home tray!! Dr Schimpff will help us to achieve these dreams with his folksy and reassuring style. This book only confirms for me that the best is yet to come!" -David B. Nash MD, MBA. Founding Dean of the Jefferson College of Population Health "As the world's older population continues to expand at an unprecedented rate, Dr. Schimpff gives readers simple steps that can lay the crucial groundwork for our future health. He provides an optimistic approach to the inevitability of aging and a refreshing perspective that our 'golden years' can also be our 'golden age, ' based on his first-hand experience as a healthcare practitioner." -E. Albert Reece, MD, PhD, MBA, Vice President for Medical Affairs, University of Maryland, John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine
Author: Caleb E. Finch
Publisher: Elsevier
ISBN: 9780080545943
Category : Medical
Languages : en
Pages : 640
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Book Description
Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309217105
Category : Social Science
Languages : en
Pages : 194
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Book Description
During the last 25 years, life expectancy at age 50 in the United States has been rising, but at a slower pace than in many other high-income countries, such as Japan and Australia. This difference is particularly notable given that the United States spends more on health care than any other nation. Concerned about this divergence, the National Institute on Aging asked the National Research Council to examine evidence on its possible causes. According to Explaining Divergent Levels of Longevity in High-Income Countries, the nation's history of heavy smoking is a major reason why lifespans in the United States fall short of those in many other high-income nations. Evidence suggests that current obesity levels play a substantial part as well. The book reports that lack of universal access to health care in the U.S. also has increased mortality and reduced life expectancy, though this is a less significant factor for those over age 65 because of Medicare access. For the main causes of death at older ages -- cancer and cardiovascular disease -- available indicators do not suggest that the U.S. health care system is failing to prevent deaths that would be averted elsewhere. In fact, cancer detection and survival appear to be better in the U.S. than in most other high-income nations, and survival rates following a heart attack also are favorable. Explaining Divergent Levels of Longevity in High-Income Countries identifies many gaps in research. For instance, while lung cancer deaths are a reliable marker of the damage from smoking, no clear-cut marker exists for obesity, physical inactivity, social integration, or other risks considered in this book. Moreover, evaluation of these risk factors is based on observational studies, which -- unlike randomized controlled trials -- are subject to many biases.
Author: Steven Johnson
Publisher: Penguin
ISBN: 0525538879
Category : Science
Languages : en
Pages : 320
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Book Description
“Offers a useful reminder of the role of modern science in fundamentally transforming all of our lives.” —President Barack Obama (on Twitter) “An important book.” —Steven Pinker, The New York Times Book Review The surprising and important story of how humans gained what amounts to an extra life, from the bestselling author of How We Got to Now and Where Good Ideas Come From In 1920, at the end of the last major pandemic, global life expectancy was just over forty years. Today, in many parts of the world, human beings can expect to live more than eighty years. As a species we have doubled our life expectancy in just one century. There are few measures of human progress more astonishing than this increased longevity. Extra Life is Steven Johnson’s attempt to understand where that progress came from, telling the epic story of one of humanity’s greatest achievements. How many of those extra years came from vaccines, or the decrease in famines, or seatbelts? What are the forces that now keep us alive longer? Behind each breakthrough lies an inspiring story of cooperative innovation, of brilliant thinkers bolstered by strong systems of public support and collaborative networks, and of dedicated activists fighting for meaningful reform. But for all its focus on positive change, this book is also a reminder that meaningful gaps in life expectancy still exist, and that new threats loom on the horizon, as the COVID-19 pandemic has made clear. How do we avoid decreases in life expectancy as our public health systems face unprecedented challenges? What current technologies or interventions that could reduce the impact of future crises are we somehow ignoring? A study in how meaningful change happens in society, Extra Life celebrates the enduring power of common goals and public resources, and the heroes of public health and medicine too often ignored in popular accounts of our history. This is the sweeping story of a revolution with immense public and personal consequences: the doubling of the human life span.
