Continuum Modeling in Mechanobiology PDF Download
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Author: Larry A. Taber
Publisher: Springer Nature
ISBN: 3030432092
Category : Technology & Engineering
Languages : en
Pages : 545
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Book Description
This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.
Author: Larry A. Taber
Publisher: Springer Nature
ISBN: 3030432092
Category : Technology & Engineering
Languages : en
Pages : 545
Get Book
Book Description
This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.
Author: Gerhard A. Holzapfel
Publisher: Springer
ISBN: 3319414755
Category : Technology & Engineering
Languages : en
Pages : 316
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Book Description
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Author: Suvranu De
Publisher: Springer
ISBN: 1447165993
Category : Technology & Engineering
Languages : en
Pages : 286
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Book Description
Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.
Author: Christopher R. Jacobs
Publisher: Garland Science
ISBN: 1135042659
Category : Medical
Languages : en
Pages : 350
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Book Description
Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope
Author: Amit Gefen
Publisher: Springer Science & Business Media
ISBN: 3642142184
Category : Technology & Engineering
Languages : en
Pages : 562
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Book Description
This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.
Author: Young W. Kwon
Publisher: CRC Press
ISBN: 1482244594
Category : Science
Languages : en
Pages : 426
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Book Description
Written to appeal to a wide field of engineers and scientists who work on multiscale and multiphysics analysis, Multiphysics and Multiscale Modeling: Techniques and Applications is dedicated to the many computational techniques and methods used to develop man-made systems as well as understand living systems that exist in nature. Presenting a body
Author: Yanhang Zhang
Publisher: Springer
ISBN: 3030201821
Category : Technology & Engineering
Languages : en
Pages : 392
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Book Description
This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Author: Oscar Gonzalez
Publisher: Cambridge University Press
ISBN: 0521886805
Category : Science
Languages : en
Pages : 5
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Book Description
The modeling and simulation of fluids, solids and other materials with significant coupling and thermal effects is becoming an increasingly important area of study in applied mathematics and engineering. Necessary for such studies is a fundamental understanding of the basic principles of continuum mechanics and thermodynamics. This book is a clear introduction to these principles. It is designed for a one- or two-quarter course for advanced undergraduate and beginning graduate students in the mathematical and engineering sciences, and is based on over nine years of teaching experience. It is also sufficiently self-contained for use outside a classroom environment. Prerequisites include a basic knowledge of linear algebra, multivariable calculus, differential equations and physics. The authors begin by explaining tensor algebra and calculus in three-dimensional Euclidean space. Using both index and coordinate-free notation, they introduce the basic axioms of continuum mechanics pertaining to mass, force, motion, temperature, energy and entropy, and the concepts of frame-indifference and material constraints. They devote four chapters to different theories of fluids and solids, and, unusually at this level, they consider both isothermal and thermal theories in detail. The book contains a wealth of exercises that support the theory and illustrate various applications. Full solutions to odd-numbered exercises are given at the end of each chapter and a complete solutions manual for all exercises is available to instructors upon request. Each chapter also contains a bibliography with references covering different presentations, further applications and numerical aspects of the theory. Book jacket.
Author: Josef Málek
Publisher: Springer Nature
ISBN: 3030880842
Category : Mathematics
Languages : en
Pages : 281
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Book Description
The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.
Author: Angela Madeo
Publisher: Elsevier
ISBN: 0081004672
Category : Technology & Engineering
Languages : en
Pages : 146
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Book Description
The new concept of metamaterial is increasingly attracting the interest of physicists and mechanical engineers. Such materials are obtained by suitably assembling multiple individual elements but usually arranged in (quasi-)periodic substructures in order to show exotic global mechanical properties. Indeed, the particular shape, geometry, size, orientation and arrangement of their constituting elements can affect, the propagation of waves of light or sound in a manner not observed in natural materials, creating material properties which may give rise to unexpected engineering applications. Particularly promising in the design and description of metamaterials are those micro-structures which present high contrasts in their mechanical properties: these micro-structures, once homogenized, may produce generalized continuum media, for example, second gradient or micromorphic. Many scientific challenges related to the application of generalized continuum theories to the characterization and conception of high-performance metamaterials can be identified. In this book we identify and discuss four main potential fields of applications of generalized continuum theories, namely, mechanical behavior of fibrous composite reinforcements, wave propagation in metamaterials, mechanical behavior of concrete and mechanically driven remodeling of bone in presence of bio-resorbable materials. For each field, we underline how the use of a generalized continuum theory can be of help for describing how the presence of microstructure can affect the global mechanical behavior of the considered metamaterials. Covers four main fields of the application of continuum theories Learn how to apply generalised continuum theory to describe the effects of microstructure on the mechanical behavior of materials Decipher the material properties which aid your engineering applications
