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Author: Zhiye Chen
Publisher: Frontiers Media SA
ISBN: 283251149X
Category : Medical
Languages : en
Pages : 90
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Book Description
Author: Zhiye Chen
Publisher: Frontiers Media SA
ISBN: 283251149X
Category : Medical
Languages : en
Pages : 90
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Book Description
Author: Elizabeth W. Loder
Publisher: Cambridge University Press
ISBN: 1107636108
Category : Medical
Languages : en
Pages : 203
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Book Description
Discussing real-world cases, this practical guide highlights areas of diagnostic uncertainty and shows common pitfalls in headache diagnosis and treatment.
Author: David Borsook
Publisher: Oxford University Press, USA
ISBN: 019975456X
Category : Health & Fitness
Languages : en
Pages : 400
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Book Description
The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
Author: Sushil Sharma
Publisher: Nova Science Publishers
ISBN: 9781634853248
Category : Personalized medicine
Languages : en
Pages : 0
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Book Description
Nova Science Publishers, New York, U.S.A has now released Personalized Medicine (Beyond PET Biomarkers), which is an extension of the authors recently published book Progress in PET Radiopharmaceuticals: Quality Control and Theranostics. In addition to recently-developed clinically-significant PET-RPs as biomarkers, this book describes various other emerging biotechnologies including: genomic medicine, nanotechnology, novel molecular biomarkers, and noninvasive imaging biotechnologies for early theranostics and personalised patient care, with minimum or no adverse effects. New therapeutic interventions including gene and cell therapies, pharmacogenomics, next generation sequencing, genome-wide association studies, proteomics, metabolomics, bioinformatics, systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigations and clinical trials, pharmacovigilance, pharmacoepidemiology, and population pharmacology are some of the most significant disciplines of predictive, precision, and personalised medicine (PM) as described in this book. More specifically, different sub-specialties of omics biotechnology including: genomic, proteomic, glycomic, lipidomic, metabolomics, metalomic, and microRNA biomarkers are described to accomplish early and personalised theranostics of chronic illnesses with currently limited therapeutic options and success. Recent advances in nanotechnology and novel biomarkers to accomplish personalised theranostics of chronic diseases including, but not limited to: cancer, fetal alcohol syndrome, Alzheimers disease, Parkinsons disease, vascular dementia, amyotrophic lateral sclerosis, and multiple sclerosis. Usually, nanoparticles (NPs) are trapped in the reticuloendothelial system (RES) comprising the lungs, liver, and spleen. To prevent their entry into the RES system and enhance drug targeting, stealth property of polyethylene glycol (PEG) as a covalent linker is utilised. However, pegylation may reduce the biological activity of the antibody or other labile molecule attached to NPs. Therefore, positively-charged chitosans and negatively charged alginates have been developed. Liposomal encapsulated Doxorubicin (Adriamycin) was approved in the early seventies for the treatment of breast cancer. In addition, enhanced permeability and retention (EPR) property of newly synthesised micro vessels of a hyper proliferating tumor is utilised to selectively invade the cancer stem cells is intricately described. Various noninvasive in-vivo imaging technologies including computerised tomography (CT), magnetic resonance imaging (MRI) along with magnetic-resonance spectroscopic (MRS) capability, single photon emission tomography (SPECT), positron emission tomography (PET), ultra sound alone or as hybrid images to obtain precise 5D anatomical landmarks, regional physiology, and biochemistry of the human body organs at cellular, molecular, and genetic level in health and disease are described. The book also describes in-vitro methods to acquire images of tissues and cells in culture employing digital infrared imaging, digital fluorescence microscopic, confocal microscopic, and fluorescence resonance transfer (FRET) resonance imaging for detecting apoptosis and/or necrosis at the cellular, molecular and genetic level. This timely-released manuscript will attract basic scientists, researchers, and physicians interested in further developing the emerging concept of personalised medicine (PM), and will serve as a textbook for Masters, M.D., and Ph. D students, and a reference book for doctors, professors, basic researchers, scientists, and general public. The author has explained recently-discovered novel biomarkers for the personalised diagnosis and treatment of cancer, cardiovascular diseases, neurodegenerative diseases, and other chronic inflammatory diseases such as asthma, COPD, cystic fibrosis, migraine, and rheumatoid arthritis to accomplish the long quested goal of evidence-based personalised theranostics (EBPT). Recently-discovered disease-specific biomarkers can be successfully employed alone or in combination for the personalised treatment of chronic multidrug-resistant illnesses. Particularly, progressive neurodegenerative diseases such as fetal alcohol syndrome, Parkinsons disease, drug addiction, Alzheimers disease, vascular dementia, amyotrophic lateral sclerosis, and demyelinating relapse and remission multiple sclerosis (RRMS) are described in detail because personalised treatment of these devastating diseases is currently a significant challenge. There are several other chronic drug resistant pro-inflammatory and infectious diseases, which could not be covered in sufficient detail owing to the lack of expertise, time, and limited space allocated to write this dedicated and clinically significant book. The author apologises to the entire global scientific community for his own ignorance, and humbly requests readers to go through the books interesting and most recent contents to enhance their basic knowledge regarding personalised medicine beyond PET biomarkers, which is one of the most demanding disciplines of modern medicine.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309288037
Category : Medical
Languages : en
Pages : 356
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Book Description
In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309316928
Category : Medical
Languages : en
Pages : 304
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Book Description
Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309157277
Category : Medical
Languages : en
Pages : 335
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Book Description
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Author: Ana Catarina Fonseca
Publisher: Springer Nature
ISBN: 303070761X
Category : Medical
Languages : en
Pages : 339
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Book Description
This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.
Author: Gaetano Santulli
Publisher: Springer
ISBN: 9783319793948
Category : Science
Languages : en
Pages : 0
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Book Description
This volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and more. Throughout, numerous color photographs, diagrams of molecular pathways, and tables enhance the text. microRNA: Basic Science is an ideal companion to both microRNA: Medical Evidenceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
Author: Dorothée Chabas
Publisher: Cambridge University Press
ISBN: 1139496514
Category : Medical
Languages : en
Pages : 297
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Book Description
Although multiple sclerosis and other disorders of myelin formation and repair are most commonly associated with adults, they can also occur in infants, children and adolescents. Up to 5 percent of those with MS experience symptoms before the age of 18, and the number of cases diagnosed is rising. There is a lack of awareness about these diseases in childhood, however, even amongst pediatric neurologists and MS specialists. Demyelinating Disorders of the Central Nervous System in Childhood provides comprehensive coverage of these diseases, highlighting throughout the differences between management in childhood and in adults. With sections dedicated to the diagnosis, course, treatment and biology of pediatric MS, detailed chapters on other childhood demyelinating diseases, including acute disseminated encephomyelitis, optic neuritis, acute complete transverse myelitis and neuromyelitis optica, are also provided. Essential reading for pediatric neurologists and MS specialists, this book will also be valuable reading for adult neurologists and pediatricians.
