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Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 1466554290
Category : Medical
Languages : en
Pages : 1152
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Book Description
Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" alon
Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 1466554290
Category : Medical
Languages : en
Pages : 1152
Get Book
Book Description
Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" alon
Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 9780824754075
Category : Medical
Languages : en
Pages : 952
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Book Description
Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding. The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.
Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 142001420X
Category : Medical
Languages : en
Pages : 950
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Book Description
Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
Author: Michael E. Peterson
Publisher: Elsevier Health Sciences
ISBN: 0323241980
Category : Medical
Languages : en
Pages : 928
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Book Description
Diagnose and determine treatment for toxic exposures in small animals with this quick reference! Small Animal Toxicology, 3rd Edition covers hundreds of potentially toxic substances, providing the information you need to manage emergency treatment and prevent poisonings in companion animals. To help you identify an unknown poison, this guide provides a list of potential toxins based on clinical signs or symptoms. It also includes a NEW color insert with 85 full-color photographs of toxic plants and of lesions associated with various poisonings. Written by respected veterinarian Michael E. Peterson and board-certified veterinary toxicologist Patricia A. Talcott, along with a team of expert contributors, this edition covers a wide variety of topics including toxicodynamics, toxicokinetics, effective history taking, recognizing clinical signs of toxic exposures, managing emergencies, and supportive care of the poisoned patient. Comprehensive coverage of toxins/poisons includes the full range of substances from acetaminophen to zinc, including home products, prescription medicines, recreational drugs, and more. Guidelines to evaluation, diagnosis and treatment include examinations of the source, toxic dose, toxicokinetics, clinical signs, minimum database, confirming tests, treatment progress and differential diagnosis for each specific toxicant. Coverage of common poisonous substances includes grapes and raisins, nicotine, mercury, mushrooms, Christmas-time plants, and snake and spider venoms. Toxicological Concepts section provides information on toxicologic principles such as history taking, providing supportive care, and managing emergency treatment. General Exposures section addresses nontraditional toxicology such as indoor environmental air, pesticides, pharmaceuticals, and toxicities in pregnant and lactating animals. Miscellaneous Toxicant Groups section covers commonly encountered specific toxicants, the proper use of diagnostic laboratories, use of human poison control centers, and antidotes for specific toxins. More than 50 international contributors provide up-to-date, authoritative advice on treating poisonings and intoxications. 8 NEW chapters cover topics including legal considerations in toxicology cases, responding to mass exposures, and poisonings in birds, small mammals, and geriatric patients. NEW color insert shows 85 of the most commonly encountered toxic substances for at-a-glance identification. UPDATED Signs and Symptoms index makes it easier to find information on a toxic agent by presenting signs rather than requiring the formulation of a diagnosis. UPDATED information on agents most likely to cause a toxic reaction includes natural flea products and an expanded section on human medications. NEW quick-access format with bold headings and convenient tables and boxes allows quick retrieval of information in emergency situations.
Author: Shayne C. Gad
Publisher: CRC Press
ISBN: 1560327693
Category : Medical
Languages : en
Pages : 419
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Book Description
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Author: Jann Hau
Publisher: CRC Press
ISBN: 1466555122
Category : Medical
Languages : en
Pages : 340
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Book Description
While replacing and reducing the use of laboratory animals are integral parts of the 3Rs—replace, reduce, refine—which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestselling previous edition, the Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models complements volumes I and II of the third edition by completing the task of providing a comprehensive overview of animal models in all biomedical disciplines. The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also presents a new chapter on applying reduction and refinement to animal models. This handbook can be used for undergraduate and postgraduate laboratory animal science courses, and as a handbook for scientists who work with animals in their research, for university veterinarians, for regulators, and for other specialists in laboratory animal science.
Author: Patricia A. Talcott
Publisher: Elsevier Health Sciences
ISBN: 1455707171
Category : Medical
Languages : en
Pages : 955
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Book Description
Diagnose and determine treatment for toxic exposures in small animals with this quick reference! Small Animal Toxicology, 3rd Edition covers hundreds of potentially toxic substances, providing the information you need to manage emergency treatment and prevent poisonings in companion animals. To help you identify an unknown poison, this guide provides a list of potential toxins based on clinical signs or symptoms. It also includes a NEW color insert with 85 full-color photographs of toxic plants and of lesions associated with various poisonings. Written by respected veterinarian Michael E. Peterson and board-certified veterinary toxicologist Patricia A. Talcott, along with a team of expert contributors, this edition covers a wide variety of topics including toxicodynamics, toxicokinetics, effective history taking, recognizing clinical signs of toxic exposures, managing emergencies, and supportive care of the poisoned patient. Comprehensive coverage of toxins/poisons includes the full range of substances from acetaminophen to zinc, including home products, prescription medicines, recreational drugs, and more. Guidelines to evaluation, diagnosis and treatment include examinations of the source, toxic dose, toxicokinetics, clinical signs, minimum database, confirming tests, treatment progress and differential diagnosis for each specific toxicant. Coverage of common poisonous substances includes grapes and raisins, nicotine, mercury, mushrooms, Christmas-time plants, and snake and spider venoms. Toxicological Concepts section provides information on toxicologic principles such as history taking, providing supportive care, and managing emergency treatment. General Exposures section addresses nontraditional toxicology such as indoor environmental air, pesticides, pharmaceuticals, and toxicities in pregnant and lactating animals. Miscellaneous Toxicant Groups section covers commonly encountered specific toxicants, the proper use of diagnostic laboratories, use of human poison control centers, and antidotes for specific toxins. More than 50 international contributors provide up-to-date, authoritative advice on treating poisonings and intoxications. 20 new chapters have been added New topics include a list of toxicants affecting body systems, management of toxins in pregnancy, diagnostic toxicology, bacterial toxins, and cosmetic/toilet articles Snake-bite injuries are treated in two separate, expanded chapters: Pit Vipers and Coral Snakes Section on pharmaceuticals includes bromides, anticonvulsants, tricycle antidepressants, monoamine oxidize inhibitors, B-adrenergic toxicities, and vitamins A and D Additional specific toxicants are covered, including Amitraz, hydramethylon, ethanol, mercury, toad toxins, poisonous frogs, salamanders, newts and venomous arthropods. Additional specific toxicants are covered, including Amitraz, hydramethylon, ethanol, mercury, toad toxins, poisonous frogs, salamanders, newts and venomous arthropods.
Author: Jann Hau
Publisher: CRC Press
ISBN: 1420084585
Category : Medical
Languages : en
Pages : 469
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Book Description
Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic
Author: David M. Kurtz
Publisher: CRC Press
ISBN: 142009114X
Category : Medical
Languages : en
Pages : 1162
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Book Description
Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.
Author: Jann Hau
Publisher: CRC Press
ISBN: 9781420084573
Category : Medical
Languages : en
Pages : 480
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Book Description
Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines. Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three R’s: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.
