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Author: Richard Chin
Publisher: CRC Press
ISBN: 1439838321
Category : Mathematics
Languages : en
Pages : 201
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Book Description
Adaptive clinical trial designs, unlike traditional fixed clinical trial designs, enable modification of studies in response to the data generated in the course of the trial. This often results in studies that are substantially faster, more efficient, and more powerful. Recent developments in web-based real-time data entry and advances in statistical methods have made adaptive clinical trials much more popular because they have become both more practical and attractive. However, there is paucity of resources that explain the mathematical framework and the practical considerations for adaptive designs without the use of highly technical statistical jargon. Suitable for readers in academia, industry, and government involved in drug development, Adaptive and Flexible Clinical Trials is the first book that comprehensively explains all essential aspects of adaptive clinical trials. Written in an easy-to-understand style aimed at clinicians and other non-statisticians, this book focuses not on the statistical details, but rather on the application of statistical concepts for adaptive clinical trials. Utilizing concrete examples, the book thoroughly explains the design, conduct, and analysis of adaptive and flexible clinical trials, allowing readers to select and design the appropriate trial designs from a conceptual perspective. From basic theory to real-life practical issues, it covers all aspects of adaptive and flexible clinical trials, including regulatory issues, interim analysis, adaptive dosing, and sequential designs.
Author: Chase Turner
Publisher: Ben Giselbach
ISBN: 9781952955051
Category : Religion
Languages : en
Pages : 204
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Book Description
If I told you the power of leaving anxiety behind and having positive, joy-filled days was as easy as reading this short book, would you believe me? No worries, I wouldn't either. However, I hope you will join me on a journey to see if you can convince yourself anxiety is a choice that we all have the power to choose to endure or let go. So many areas in our lives cause us anxiety, stress, worry, depression, etc. When we consider all the trigger points for these challenges we face, we must find the root or the core of what brings all these negative feelings and emotions. One of the underlying struggles we all deal with is the desire to be normal. We never want others to look at us and think we aren't "normal," or better put, "like them" (from our own perspective). When we look at the world around us, don't we find the biggest group of people who seem to be similar, and then we try to be like them because they are the "normal" ones? It feels silly just saying those words, but so many live by them. Do we really want to be like everyone else? The T.R.I.A.L.S. method has helped me in my journey to help others reduce stress in their lives. I have developed this acronym hoping to help us all find practical ways to overcome stressful situations and anxiety. T = Transparency R = Responsibility I = Intentionality A = Appreciation L = Limits S = Simplify At the end of each section, we will look at practical ways to implement these principles to reduce your current stress levels. There will also be a section of discussion questions at the end of each chapter to use for personal growth or group studies. Understanding T.R.I.A.L.S. has the potential to bring a tremendous amount of joy to your life. I encourage you to have an open mind and be optimistic about the possibility of reducing your stress and eliminating anxiety from your daily routine. The power to choose lies within you!
Author: Cordelia K. Castel
Publisher:
ISBN:
Category :
Languages : en
Pages : 504
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Book Description
Thirty young women. A handsome prince. A battle to the death Water is scarce. Deserts have taken over the land. Nuclear war has devastated humanity. Humans live in walled super cities to keep out the irradiated. The land that was formerly known as America is divided into kingdoms ruled by royal elites.Born into the lowest Echelon of the Kingdom of Phangloria, sixteen-year-old Zea Calico faces a life of hunger, thirst, and toil. The only way out of this drudgery is revolution, and Zea is desperate to help the cause. When the palace calls for candidates to compete to marry Prince Kevon, Zea joins the Princess Trials to search the palace for weaknesses. The trials should be a fairytale of sumptuous meals, ballgowns, and romance, but one misplaced word causes Zea to attract the Prince's attention. When Zea uncovers the man beneath Prince Kevon's public facade, she is at risk of falling in love and losing sight of her mission. But the televised beauty pageant turns deadly, and Zea must fight for survival.Perfect for fans of The Hunger Games and The Selection, this exciting tale of courage, intrigue, and betrayal will have you turning pages.
Author: Emily L Thuma
Publisher: University of Illinois Press
ISBN: 0252051173
Category : Social Science
Languages : en
Pages : 380
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Book Description
During the 1970s, grassroots women activists in and outside of prisons forged a radical politics against gender violence and incarceration. Emily L. Thuma traces the making of this anticarceral feminism at the intersections of struggles for racial and economic justice, prisoners’ and psychiatric patients’ rights, and gender and sexual liberation. All Our Trials explores the organizing, ideas, and influence of those who placed criminalized and marginalized women at the heart of their antiviolence mobilizations. This activism confronted a "tough on crime" political agenda and clashed with the mainstream women’s movement’s strategy of resorting to the criminal legal system as a solution to sexual and domestic violence. Drawing on extensive archival research and first-person narratives, Thuma weaves together the stories of mass defense campaigns, prisoner uprisings, broad-based local coalitions, national gatherings, and radical print cultures that cut through prison walls. In the process, she illuminates a crucial chapter in an unfinished struggle––one that continues in today’s movements against mass incarceration and in support of transformative justice.
Author: N. E. Davenport
Publisher: HarperCollins
ISBN: 0063058502
Category : Fiction
Languages : en
Pages : 429
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Book Description
Blending fantasy and science fiction, N. E. Davenport’s fast-paced, action-packed debut kicks off a duology of loyalty and rebellion, in which a young Black woman must survive deadly trials in a racist and misogynistic society to become an elite warrior. It’s all about blood. The blood spilled between the Republic of Mareen and the armies of the Blood Emperor long ago. The blood gifts of Mareen’s deadliest enemies. The blood that runs through the elite War Houses of Mareen, the rulers of the Tribunal dedicated to keeping the republic alive. The blood of the former Legatus, Verne Amari, murdered. For his granddaughter, Ikenna, the only thing steady in her life was the man who had saved Mareen. The man who had trained her in secret, not just in martial skills, but in harnessing the blood gift that coursed through her. Who trained her to keep that a secret. But now there are too many secrets, and with her grandfather assassinated, Ikenna knows two things: that only someone on the Tribunal could have ordered his death, and that only a Praetorian Guard could have carried out that order. Bent on revenge as much as discovering the truth, Ikenna pledges herself to the Praetorian Trials—a brutal initiation that only a quarter of the aspirants survive. She subjects herself to the racism directed against her half-Khanaian heritage and the misogyny of a society that cherishes progeny over prodigy, all while hiding a power that—if found out—would subject her to execution…or worse. Ikenna is willing to risk it all because she needs to find out who murdered her grandfather…and then she needs to kill them. Mareen has been at peace for a long time… Ikenna joining the Praetorians is about to change all that. Magic and technology converge in the first part of this stunning debut duology, where loyalty to oneself—and one’s blood—is more important than anything.
Author: National Research Council
Publisher: National Academies Press
ISBN: 030918651X
Category : Medical
Languages : en
Pages : 163
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Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Author: Alisha Rankin
Publisher: University of Chicago Press
ISBN: 9780226744858
Category : Science
Languages : en
Pages : 0
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Book Description
In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
Author: Paul DerOhannesian (II)
Publisher: Lexis Law Publishing (Va)
ISBN:
Category : Child sexual abuse
Languages : en
Pages : 824
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Book Description
Author:
Publisher:
ISBN: 9781668714775
Category :
Languages : en
Pages : 0
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Book Description
Author: Richard Chin
Publisher: CRC Press
ISBN: 1439838321
Category : Mathematics
Languages : en
Pages : 201
Get Book
Book Description
Adaptive clinical trial designs, unlike traditional fixed clinical trial designs, enable modification of studies in response to the data generated in the course of the trial. This often results in studies that are substantially faster, more efficient, and more powerful. Recent developments in web-based real-time data entry and advances in statistical methods have made adaptive clinical trials much more popular because they have become both more practical and attractive. However, there is paucity of resources that explain the mathematical framework and the practical considerations for adaptive designs without the use of highly technical statistical jargon. Suitable for readers in academia, industry, and government involved in drug development, Adaptive and Flexible Clinical Trials is the first book that comprehensively explains all essential aspects of adaptive clinical trials. Written in an easy-to-understand style aimed at clinicians and other non-statisticians, this book focuses not on the statistical details, but rather on the application of statistical concepts for adaptive clinical trials. Utilizing concrete examples, the book thoroughly explains the design, conduct, and analysis of adaptive and flexible clinical trials, allowing readers to select and design the appropriate trial designs from a conceptual perspective. From basic theory to real-life practical issues, it covers all aspects of adaptive and flexible clinical trials, including regulatory issues, interim analysis, adaptive dosing, and sequential designs.
Author: Henry A. Glick
Publisher: Handbooks in Health Economic E
ISBN: 0199685029
Category : Business & Economics
Languages : en
Pages : 265
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Book Description
It is increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. This book provides a practical guide to the techniques and issues involved in conducting economic evaluation in ongoing clinical trials, supported with examples.
