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Author: Michael F.W. Festing
Publisher: Springer
ISBN: 1349042013
Category : Medical
Languages : en
Pages : 263
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Book Description
Author: Stanley J. Ulijaszek
Publisher: Cambridge University Press
ISBN: 1108515150
Category : Social Science
Languages : en
Pages : 250
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Book Description
Taking a comparative approach, this book investigates the ways in which obesity and its susceptibilities are framed in science and policy and how they might work better. Providing a clear, authoritative voice on the debate, the author builds on early work to engage further in ecological and complexity thinking in obesity. Many of the models that have emerged since obesity became a population-level issue are examined, including the energy balance model, and models used to examine human body fatness from a range of perspectives including evolutionary, anthropological, environmental, and political viewpoints. The book is ideal for those working on, or interested in, obesity science, health policy, health economics, evolutionary medicine, medical sociology, nutrition and public health who want to understand the shifts that have taken place in obesity science, policy, and intervention in the past forty years.
Author: Michael F.W. Festing
Publisher: Springer
ISBN: 1349042013
Category : Medical
Languages : en
Pages : 263
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Book Description
Author: George G. Nomikos
Publisher: Academic Press
ISBN: 0128031646
Category : Medical
Languages : en
Pages : 458
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Book Description
Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia
Author: Patrick C. Even
Publisher: Frontiers Media SA
ISBN: 2889454258
Category :
Languages : en
Pages : 161
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Book Description
Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
Author: Michael Francis Wogan Festing
Publisher:
ISBN: 9780333253397
Category : Obesity
Languages : en
Pages : 258
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Book Description
Author: Claude Bouchard
Publisher: CRC Press
ISBN: 1000141608
Category : Medical
Languages : en
Pages : 262
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Book Description
This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.
Author: Wiley
Publisher: John Wiley & Sons
ISBN: 1118734297
Category : Medical
Languages : en
Pages : 194
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Book Description
With the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.
Author: Stanley J. Ulijaszek
Publisher: Cambridge University Press
ISBN: 1107117518
Category : Business & Economics
Languages : en
Pages : 249
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Book Description
Rationalities and models of obesity -- Energy balance, genetics and obesogenic environments -- Governance through measurement -- Inequalities -- Food and eating -- Global transformations of diet -- Obesity science and policy -- Complexity -- Systems and rationalities
Author: Bartholomew Ibeh
Publisher: BoD – Books on Demand
ISBN: 1789231647
Category : Science
Languages : en
Pages : 410
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Book Description
The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309089964
Category : Medical
Languages : en
Pages : 277
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Book Description
The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.
