Discoveries in Pharmacological Sciences PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Discoveries in Pharmacological Sciences PDF full book. Access full book title Discoveries in Pharmacological Sciences by Popat N. Patil. Download full books in PDF and EPUB format.
Author: Popat N. Patil
Publisher: World Scientific
ISBN: 9814355070
Category : Medical
Languages : en
Pages : 793
Get Book
Book Description
Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This unique book, Discoveries in Pharmacological Sciences, contains the history of herbal medicine as it emerged about 5,000 years ago. Recent discoveries in genetics are integrated with the observations in the past. An understanding of the history of drugs and toxic chemicals is essential for the proper utility of these substances by the population at large. The book is written with the purpose to familiarize drug research of the investigators in chemical, pharmaceutical, pharmacological, and biomedical sciences. It is important to note that plants containing morphine, quinine, physostigmine, pilocarpine, atropine, d-tubocurarine, reserpine, tetrahydrocannabinol, cardiac glycosides, ephedrine and colchicine were used by various cultures for centuries. Since 1805 pure, active, therapeutic constituents were isolated and chemically characterized. Parallel to these developments, the science of human anatomy, physiology, biochemistry, genetics and pharmacology has advanced. New synthetic drugs were discovered. The chemistry of perfumes and sensory functions including memory were elucidated. The history of fascinating discoveries made by scientists of Nobel repute is documented. Better testing methods were developed. The causes of many diseases were better understood. Drug laws were instituted a century ago. The pharmaceutical industry flourished. The text provides a panoramic view of the understanding of when, where, who, how and why drugs were developed. Educational aspects of teaching pharmacological sciences are reviewed. The historical account will be invaluable to graduate students and creative scientists, who can prepare for the future. The book will serve to enhance the cumulative scientific knowledge of the investigators in drug discovery. It contains a well integrated wealth of information in drug sciences and pharmacotherapeutics. The time, place and the human side of investigators, their portraits with biographical sketches are presented. The reading of Discoveries in Pharmacological Sciences will satisfy the intellectual curiosity of investigators. Understanding of Discoveries in Pharmacological Sciences will provide a platform to judge the importance of the personalized medicine of tomorrow. Scattered classical information about drug sciences is effectively condensed here. The development of the scientific thoughts and creativity of the investigators through the ages in drug research are presented admirably.
Author: Popat N. Patil
Publisher: World Scientific
ISBN: 9814355070
Category : Medical
Languages : en
Pages : 793
Get Book
Book Description
Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This unique book, Discoveries in Pharmacological Sciences, contains the history of herbal medicine as it emerged about 5,000 years ago. Recent discoveries in genetics are integrated with the observations in the past. An understanding of the history of drugs and toxic chemicals is essential for the proper utility of these substances by the population at large. The book is written with the purpose to familiarize drug research of the investigators in chemical, pharmaceutical, pharmacological, and biomedical sciences. It is important to note that plants containing morphine, quinine, physostigmine, pilocarpine, atropine, d-tubocurarine, reserpine, tetrahydrocannabinol, cardiac glycosides, ephedrine and colchicine were used by various cultures for centuries. Since 1805 pure, active, therapeutic constituents were isolated and chemically characterized. Parallel to these developments, the science of human anatomy, physiology, biochemistry, genetics and pharmacology has advanced. New synthetic drugs were discovered. The chemistry of perfumes and sensory functions including memory were elucidated. The history of fascinating discoveries made by scientists of Nobel repute is documented. Better testing methods were developed. The causes of many diseases were better understood. Drug laws were instituted a century ago. The pharmaceutical industry flourished. The text provides a panoramic view of the understanding of when, where, who, how and why drugs were developed. Educational aspects of teaching pharmacological sciences are reviewed. The historical account will be invaluable to graduate students and creative scientists, who can prepare for the future. The book will serve to enhance the cumulative scientific knowledge of the investigators in drug discovery. It contains a well integrated wealth of information in drug sciences and pharmacotherapeutics. The time, place and the human side of investigators, their portraits with biographical sketches are presented. The reading of Discoveries in Pharmacological Sciences will satisfy the intellectual curiosity of investigators. Understanding of Discoveries in Pharmacological Sciences will provide a platform to judge the importance of the personalized medicine of tomorrow. Scattered classical information about drug sciences is effectively condensed here. The development of the scientific thoughts and creativity of the investigators through the ages in drug research are presented admirably.
Author: Popat N Patil
Publisher: World Scientific
ISBN: 981445866X
Category : Medical
Languages : en
Pages : 792
Get Book
Book Description
Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This unique book, Discoveries in Pharmacological Sciences, contains the history of herbal medicine as it emerged about 5,000 years ago. Recent discoveries in genetics are integrated with the observations in the past. An understanding of the history of drugs and toxic chemicals is essential for the proper utility of these substances by the population at large. The book is written with the purpose to familiarize drug research of the investigators in chemical, pharmaceutical, pharmacological, and biomedical sciences. It is important to note that plants containing morphine, quinine, physostigmine, pilocarpine, atropine, d-tubocurarine, reserpine, tetrahydrocannabinol, cardiac glycosides, ephedrine and colchicine were used by various cultures for centuries. Since 1805 pure, active, therapeutic constituents were isolated and chemically characterized. Parallel to these developments, the science of human anatomy, physiology, biochemistry, genetics and pharmacology has advanced. New synthetic drugs were discovered. The chemistry of perfumes and sensory functions including memory were elucidated. The history of fascinating discoveries made by scientists of Nobel repute was documented. Better testing methods were developed. The causes of many diseases were better understood. Drug laws were instituted a century ago. The pharmaceutical industry flourished. The text provides a panoramic view of the understanding of when, where, who, how and why drugs were developed. Educational aspects of teaching pharmacological sciences are reviewed. The historical account will be invaluable to graduate students and creative scientists, who can prepare for the future. The book will serve to enhance the cumulative scientific knowledge of the investigators in drug discovery. It contains a well integrated wealth of information in drug sciences and pharmacotherapeutics. The time, place and the human side of investigators, their portraits with biographical sketches are presented. The reading of Discoveries in Pharmacological Sciences will satisfy the intellectual curiosity of investigators. Understanding of Discoveries in Pharmacological Sciences will provide a platform to judge the importance of the personalized medicine of tomorrow. Scattered classical information about drug sciences is effectively condensed here. The development of the scientific thoughts and creativity of the investigators through the ages in drug research are presented admirably. Contents:Drug Discoveries:Evolution, Human Migration, Diseases and TreatmentsAncient Medicine and the Discovery of Natural Therapeutic AgentsHistory of Anesthesia, Acupuncture, Hypnosis, Mesmerism, Anesthetics and HypnoticsEmergence of Modern MedicineContributions of Anatomists and Physiologists to the Neurofunctional Outline of the Nervous System20th Century Drug Discoveries Research, Pharmacology Education, Laws and Pharmaceutical Companies:Pharmacology Comes of AgeDiscovery of Receptors and Related Events: A Century of Receptors and TransductionDevelopment of Drug Laws and QuantitationDrug DiscoveriesGrowth of the Drug Industry, Research Institutions and Universities Readership: Professionals (pharmacologists, chemists, physicians, science teachers); students (BS, MS, PharmD, PhD); general public with an interest in life sciences. Keywords:Morphine;Chemistry;Anatomy;Andreas Vesalius;William Harvey's Discovery of Circulation Physiology;Leeuwenhoek's MicroscopyReviews: “The author offers rare insight into interactions between different cultures as some traditional practices were common to more than a few societies. Anyone with at least some science background and some interest in drug discovery will find the work engaging. Audiences include medicinal chemists, graduate students in ethnopharmacological sciences, undergraduate pharmacy students, and informed general readers.” CHOICE
Author: Terry P. Kenakin
Publisher: Academic Press
ISBN: 0123848563
Category : Medical
Languages : en
Pages : 261
Get Book
Book Description
This resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process.
Author: Tamas Bartfai
Publisher: Academic Press
ISBN: 0124095194
Category : Medical
Languages : en
Pages : 376
Get Book
Book Description
The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease. Provides an in-depth, broad perspective on the crisis in drug industry Exposes the disconnect between what society needs and what the drug companies are working on Analyses and projects over 10 years into the future Explains what it means for scientists and society Determines what is needed to be done to make sure that the industry responds to society's needs, remains commercially attractive and answers the question as to who decides which diseases to treat
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128096926
Category : Science
Languages : en
Pages : 332
Get Book
Book Description
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
Author: Bhushan Patwardhan
Publisher: Academic Press
ISBN: 0128018224
Category : Medical
Languages : en
Pages : 480
Get Book
Book Description
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Author: Andrea Trabocchi
Publisher: Elsevier
ISBN: 0128183500
Category : Science
Languages : en
Pages : 358
Get Book
Book Description
Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Author: Terry Kenakin
Publisher: Academic Press
ISBN: 0128037539
Category : Medical
Languages : en
Pages : 350
Get Book
Book Description
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history Offers sample questions throughout the book and an appendix containing answers for self-testing and retention
Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 111835446X
Category : Medical
Languages : en
Pages : 572
Get Book
Book Description
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Author: Edward D. Zanders
Publisher: Springer Science & Business Media
ISBN: 1441999027
Category : Medical
Languages : en
Pages : 397
Get Book
Book Description
The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the nineteen chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators.
