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Author: William E Schiesser
Publisher: World Scientific Publishing Company
ISBN: 9813207477
Category :
Languages : en
Pages : 172
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Book Description
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND. The format and emphasis of the presentation is based on the following elements: A statement of the PDE system, including initial conditions (ICs), boundary conditions (BCs) and the model parameters.Algorithms for the calculation of numerical solutions of the PDE system with a minimum of mathematical formality.A set of R routines for the calculation of numerical solutions, including a detailed explanation of all of the sections of the code. The R routines can be executed after a straightforward download of R, an open-source scientific computing system available from the Internet.Presentation of the numerical solutions, particularly in graphical (plotted) format to enhance the visualization of the solution.Summary and conclusions concerning the principal results from the model that might serve as the basis for a next step in the modeling of ND. In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest. These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem. Request Inspection Copy
Author: William E Schiesser
Publisher: World Scientific Publishing Company
ISBN: 9813207477
Category :
Languages : en
Pages : 172
Get Book
Book Description
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND. The format and emphasis of the presentation is based on the following elements: A statement of the PDE system, including initial conditions (ICs), boundary conditions (BCs) and the model parameters.Algorithms for the calculation of numerical solutions of the PDE system with a minimum of mathematical formality.A set of R routines for the calculation of numerical solutions, including a detailed explanation of all of the sections of the code. The R routines can be executed after a straightforward download of R, an open-source scientific computing system available from the Internet.Presentation of the numerical solutions, particularly in graphical (plotted) format to enhance the visualization of the solution.Summary and conclusions concerning the principal results from the model that might serve as the basis for a next step in the modeling of ND. In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest. These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem. Request Inspection Copy
Author: W. E. Schiesser
Publisher:
ISBN: 9789813207462
Category :
Languages : en
Pages :
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Book Description
Author: John H. Byrne
Publisher: Oxford University Press
ISBN: 0190456787
Category : Science
Languages : en
Pages : 608
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Book Description
Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.
Author: Charles J. Epstein
Publisher: Oxford University Press, USA
ISBN: 019514502X
Category : Medical
Languages : en
Pages : 1110
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Book Description
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Author: William E. Schiesser
Publisher: Cambridge University Press
ISBN: 0521519861
Category : Computers
Languages : en
Pages : 491
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Book Description
Presents numerical methods and computer code in Matlab for the solution of ODEs and PDEs with detailed line-by-line discussion.
Author: Khawaja Husnain Haider
Publisher: Springer Nature
ISBN: 9811926557
Category : Science
Languages : en
Pages : 1527
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Book Description
The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.
Author: C. A. Silebi
Publisher: Elsevier
ISBN: 0080925820
Category : Science
Languages : en
Pages : 518
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Book Description
This book presents a methodology for the development and computer implementation of dynamic models for transport process systems. Rather than developing the general equations of transport phenomena, it develops the equations required specifically for each new example application. These equations are generally of two types: ordinary differential equations (ODEs) and partial differential equations (PDEs) for which time is an independent variable. The computer-based methodology presented is general purpose and can be applied to most applications requiring the numerical integration of initial-value ODEs/PDEs. A set of approximately two hundred applications of ODEs and PDEs developed by the authors are listed in Appendix 8.
Author: William E. Schiesser
Publisher: Elsevier
ISBN: 0128015519
Category : Mathematics
Languages : en
Pages : 326
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Book Description
This is the first book on the numerical method of lines, a relatively new method for solving partial differential equations. The Numerical Method of Lines is also the first book to accommodate all major classes of partial differential equations. This is essentially an applications book for computer scientists. The author will separately offer a disk of FORTRAN 77 programs with 250 specific applications, ranging from "Shuttle Launch Simulation" to "Temperature Control of a Nuclear Fuel Rod."
Author: Amal Kumar Dhara
Publisher: Springer Nature
ISBN: 9819977037
Category :
Languages : en
Pages : 637
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Book Description
Author: Sumeet Dua
Publisher: World Scientific
ISBN: 9814340294
Category : Technology & Engineering
Languages : en
Pages : 467
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Book Description
Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.
