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Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 981108064X
Category : Science
Languages : en
Pages : 564
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Book Description
This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.
Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 981108064X
Category : Science
Languages : en
Pages : 564
Get Book
Book Description
This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.
Author: Sonia Malik
Publisher: Springer
ISBN: 3319538802
Category : Science
Languages : en
Pages : 328
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Book Description
This book discusses cancers and the resurgence of public interest in plant-based and herbal drugs. It also describes ways of obtaining anti-cancer drugs from plants and improving their production using biotechnological techniques. It presents methods such as cell culture, shoot and root culture, hairy root culture, purification of plant raw materials, genetic engineering, optimization of culture conditions as well as metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. In addition, it describes the applications and limitations of large-scale production of anti-cancer compounds using biotechnological means. Lastly, it discusses future economical and eco-friendly strategies for obtaining anti-cancer compounds using biotechnology.
Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 9811082162
Category : Science
Languages : en
Pages : 322
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Book Description
Cancer is one of the leading causes of death in human beings. Though several synthetic medicines are used to treat cancer, they are largely inefficient and unsafe. In contrast, plants, which have been used for medicinal purposes since time immemorial, have proved to be useful in fighting cancer, with natural compounds from plants and their derivatives offering safe and effective treatment and management for several types of cancer. Plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their value in the treatment of cancer and various other infectious diseases, and several common anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Unfortunately, many of these anticancer plants have become endangered due to ruthless and irresponsible harvesting practices. Hence, there is a need to conserve these species and to propagate them on a large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology could be adopted to produce these anticancer compounds without the need for cultivation. A better grasp and continuing exploration of these isolated molecules and products could provide a powerful alternative means of reducing cancer risk. “Anticancer Plants: Volume 3, Clinical Trials and Nanotechnology” provides a timely review of concepts and experimental data on the application of anticancer plants and their compounds in clinical trials, and on the use of nanotechnology in cancer therapy.
Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 981108548X
Category : Science
Languages : en
Pages : 582
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Book Description
Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.
Author: Gordon M. Cragg
Publisher: CRC Press
ISBN: 1420039652
Category : Medical
Languages : en
Pages : 610
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Book Description
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 9811084173
Category : Science
Languages : en
Pages : 360
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Book Description
This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. The book provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research.
Author: Anupam Bishayee
Publisher: MDPI
ISBN: 3038973106
Category : Electronic books
Languages : en
Pages : 285
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Book Description
This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients
Author: Rouf Ahmad Bhat
Publisher: Academic Press
ISBN: 0128241101
Category : Science
Languages : en
Pages : 776
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Book Description
Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion. Discusses phytotherapeutic properties for a wide range of medical conditions, including anti-pyretic, anti-infective, anti-malarial, Anti-AIDS, anti-diabetic, anti-cancerous, immune-modulatory applications Includes a discussion of synergistic effects of formulations and antagonistic drug interactions Addresses advancements and achievements of novel plant-based drugs using molecular, enzymatic activities and various technological tools in an eco-friendly fashion
Author: Bruce C. Baguley
Publisher: Elsevier
ISBN: 0080490441
Category : Medical
Languages : en
Pages : 397
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Book Description
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching
Author: Victor Kuete
Publisher: World Scientific
ISBN: 9814583529
Category : Science
Languages : en
Pages : 412
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Book Description
This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin. The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms. Contents:Biodiversity of Medicinal Plants (Kirsten Yacoub, Katharina Cibis and Corinna Risch)Biodiversity and Metagenomics (Eva-Maria Surmann and Thomas Efferth)Chemical Ecology of Medicinal Plants (Christian Kersten, Stephanie Lenz and Janina Wich)Chemical Ecology of Marine Organisms (André Antunes and Thomas Efferth)Natural Products from Terrestrial Microbial Organisms with Cytotoxic Cell Cycle Inhibitors (Theresa Dreis, Caroline Gartner, Julia Krebs and Mathias Schneider)Marine Compounds (Jennifer Honek and Thomas Efferth)Ethnopharmacology and Phytotherapy (Ariane Löhnert, Susanne Löhnert, Viktoriya Mogilevskaya and Sandra Schick)Contribution of African Flora in a Global Fight Against Cancer (Victor Kuete and Thomas Efferth)Natural Products Derived from Terrestrial Plants with Activity Towards Cancer Cells (Sonia Falenska, Ina Kirmes, Stephanie Kletting, Irini Karagianni and Karen Duffy)Established Anticancer Drugs from Natural Origin (Clara Becker, Kerstin Hoffmann, Laura Hoffmann, Tanya King, Franziska Faulstich, Katrin Viertel, Victor Kuete and Thomas Efferth) Readership: Graduate students and scientists in pharmaceutical sciences, pharmacology, organic chemistry, biochemistry, pharmacognosy, phytochemistry, ethnomedicine & ethnopharmacology, compementary & alternative medicine, public health. Key Features:This book is the first of its kind bringing together biodiversity, chemical ecology, phytochemistry and cancer therapyThe book provides the state-of-the-art in anticancer discovery from medicinal plantsThe book also provides the state-of-the-art in anticancer discovery from marine organismsKeywords:Biodiversity;Cancer;Marine Products;Natural Products;Established Drugs
